ArticlePloS one2011
The N-terminal amphipathic helix of the topological specificity factor MinE is associated with shaping membrane curvature.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli.The Journal of cell biology · 2025Article
- Machine learning-aided design and screening of an emergent protein function in synthetic cells.Nature communications · 2024Article
- The mechanism of MinD stability modulation by MinE in Min protein dynamics.PLoS computational biology · 2023Article
- Strategic optimization of conditions for the solubilization of GST-tagged amphipathic helix-containing ciliary proteins overexpressed as inclusion bodies in E. coli.Microbial cell factories · 2022Article
- ADP-Ribosylation Factor Family of Small GTP-Binding Proteins: Their Membrane Recruitment, Activation, Crosstalk and Functions.Frontiers in cell and developmental biology · 2022Review
- Mass-sensitive particle tracking to elucidate the membrane-associated MinDE reaction cycle.Nature methods · 2021Article
- The E. coli MinCDE system in the regulation of protein patterns and gradients.Cellular and molecular life sciences : CMLS · 2019Review
- Mechanistic insights of the Min oscillator via cell-free reconstitution and imaging.Physical biology · 2018Review
- Large-scale modulation of reconstituted Min protein patterns and gradients by defined mutations in MinE's membrane targeting sequence.PloS one · 2017Article
- Article
- Quantitative Proteomics Analysis Reveals the Min System of Escherichia coli Modulates Reversible Protein Association with the Inner Membrane.Molecular & cellular proteomics : MCP · 2016Article
- Membrane-bound MinDE complex acts as a toggle switch that drives Min oscillation coupled to cytoplasmic depletion of MinD.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An Optimal Free Energy Dissipation Strategy of the MinCDE Oscillator in Regulating Symmetric Bacterial Cell Division.PLoS computational biology · 2015Article
- Article
- Proteome-wide subcellular topologies of E. coli polypeptides database (STEPdb).Molecular & cellular proteomics : MCP · 2014Article
- Toward the assembly of a minimal divisome.Systems and synthetic biology · 2014Review
- Self-assembly of MinE on the membrane underlies formation of the MinE ring to sustain function of the Escherichia coli Min system.The Journal of biological chemistry · 2014Article
- Differential affinities of MinD and MinE to anionic phospholipid influence Min patterning dynamics in vitro.Molecular microbiology · 2014Article
- Arabidopsis CURVATURE THYLAKOID1 proteins modify thylakoid architecture by inducing membrane curvature.The Plant cell · 2013Article
- Membrane association via an amino-terminal amphipathic helix is required for the cellular organization and function of RNase II.The Journal of biological chemistry · 2013Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pole-to-pole oscillations of the Min proteins in Escherichia coli are required for the proper placement of the division septum. Direct interaction of MinE with the cell membrane is critical for the dynamic behavior of the Min system. In vitro, this MinE-membrane interaction led to membrane deformation; however, the underlying mechanism remained unclear. Here we report that MinE-induced membrane deformation involves the formation of an amphipathic helix of MinE(2-9), which, together with the adjacent basic residues, function as membrane anchors. Biochemical evidence suggested that the membrane association induces formation of the helix, with the helical face, consisting of A2, L3, and F6, inserted into the membrane. Insertion of this helix into the cell membrane can influence local membrane curvature and lead to drastic changes in membrane topology. Accordingly, MinE showed characteristic features of protein-induced membrane tubulation and lipid clustering in in vitro reconstituted systems. In conclusion, MinE shares common protein signatures with a group of membrane trafficking proteins in eukaryotic cells. These MinE signatures appear to affect membrane curvature.
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