ArticleFrontiers in cellular neuroscience2011
The role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.
Article in Frontiers in cellular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 73 citations in OpenAlex.
- Autism-associated ARHGEF9 variants impair GABAergic synapses and ultrasonic communication by reducing gephyrin phosphorylation.Molecular psychiatry · 2026Article
- Foxp2 mutations and abnormal brain and gastrointestinal development: insights from animal models of speech-language and autism spectrum disorders.Frontiers in neuroanatomy · 2026Review
- Critical Role of Rho Guanine Nucleotide Exchange Factor 4 in Brain Function.Molecular neurobiology · 2025Article
- Impaired axon initial segment structure and function in a model ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cellular and Molecular Mechanisms Regulating Retinal Synapse Development.Annual review of vision science · 2024Review
- Impact of Developmental Changes of GABAInternational journal of molecular sciences · 2023Article
- Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether.International journal of molecular sciences · 2022Article
- Deciphering the conformational dynamics of gephyrin-mediated collybistin activation.Biophysical reports · 2022Article
- Activity-Induced Cortical Glutamatergic Neuron Nascent Proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAMolecular psychiatry · 2022Article
- Differential modulation of collybistin conformational dynamics by the closely related GTPases Cdc42 and TC10.Frontiers in synaptic neuroscience · 2022Article
- Gene Therapy: Novel Approaches to Targeting Monogenic Epilepsies.Frontiers in neurology · 2022Review
- Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021Article
- The role of GABAergic signalling in neurodevelopmental disorders.Nature reviews. Neuroscience · 2021Review
- Plasticity in the Hippocampus, Neurogenesis and Drugs of Abuse.Brain sciences · 2021Review
- A proline-rich motif in the large intracellular loop of the glycine receptor α1 subunit interacts with the Pleckstrin homology domain of collybistin.Journal of advanced research · 2021Article
- Neuroligin-2 dependent conformational activation of collybistin reconstituted in supported hybrid membranes.The Journal of biological chemistry · 2020Article
- Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations.International journal of molecular sciences · 2020Review
- Clinical and Molecular Characterization of Three Novel ARHGEF9 Mutations in Patients with Developmental Delay and Epilepsy.Journal of molecular neuroscience : MN · 2020Article
- Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system.Neural development · 2018Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collybistin (Cb) is a brain-specific GDP/GTP-exchange factor, which interacts with the inhibitory receptor anchoring protein gephyrin. Data from mice carrying an inactivated Cb gene indicate that Cb is required for the formation and maintenance of gephyrin and gephyrin-dependent GABA(A) receptor (GABA(A)R) clusters at inhibitory postsynapses in selected regions of the mammalian forebrain. However, important aspects of how Cb's GDP/GTP-exchange activity, structure, and regulation contribute to gephyrin and GABA(A)R clustering, as well as its role in synaptic plasticity, remain poorly understood. Here we review the current state of knowledge about Cb's function and address open questions concerning its contribution to synapse formation, maintenance, plasticity, and adaptive changes in response to altered network activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.