ArticleFrontiers in cellular neuroscience2011
Postnatal development of dendrodendritic inhibition in the Mammalian olfactory bulb.
Article in Frontiers in cellular neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.PLoS biology · 2024Article
- Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb.bioRxiv : the preprint server for biology · 2024Article
- Early development of olfactory circuit function.Frontiers in cellular neuroscience · 2023Review
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- αFrontiers in cellular neuroscience · 2022Article
- Article
- Dendritic integration in olfactory bulb granule cells upon simultaneous multispine activation: Low thresholds for nonlocal spiking activity.PLoS biology · 2020Article
- Local Postsynaptic Signaling on Slow Time Scales in Reciprocal Olfactory Bulb Granule Cell Spines Matches Asynchronous Release.Frontiers in synaptic neuroscience · 2020Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Haploinsufficiency of autism causative geneMolecular autism · 2019Article
- Inhibitory circuits of the mammalian main olfactory bulb.Journal of neurophysiology · 2017Review
- Postnatal Odor Exposure Increases the Strength of Interglomerular Lateral Inhibition onto Olfactory Bulb Tufted Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Sniff-Like Patterned Input Results in Long-Term Plasticity at the Rat Olfactory Bulb Mitral and Tufted Cell to Granule Cell Synapse.Neural plasticity · 2016Article
- Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling.Journal of neurophysiology · 2015Article
- Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.Physiological reports · 2015Article
- Age-dependent adrenergic actions in the main olfactory bulb that could underlie an olfactory-sensitive period.Journal of neurophysiology · 2012Article
- Lithium prevents long-term neural and behavioral pathology induced by early alcohol exposure.Neuroscience · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mitral-granule cell (MC-GC) reciprocal synapse is an important source of auto- and lateral-inhibition in the olfactory bulb (OB), and this local inhibition is critical for odor discrimination. We may gain insight into the role of MC autoinhibition in olfaction by correlating the functional development of the autoinhibition with the postnatal development of olfactory function. We have studied the functional development of the MC-GC reciprocal synapse using whole-cell patch-clamp recordings from MCs and GCs in acute OB slices from 3- to 30-day-old rats. The magnitude of dendrodendritic inhibition (DDI) measured by depolarizing a single MC and recording recurrent inhibition in the same cell increased up to the fifteenth day of life (P15), but dropped between P15 and P30. The initial increase and later decrease in DDI was echoed by a similar increase and decrease in the frequency of miniature inhibitory post-synaptic currents, suggesting an accompanying modulation in the number of synapses available to participate in DDI. The late decrease in DDI could also result, in part, from a decrease in GC excitability as well as an increase in relative contribution of N-methyl d-aspartate (NMDA) receptors to γ-amino butyric acid (GABA) release from GC synapses. Changes in release probability of GABAergic synapses are unlikely to account for the late reduction in DDI, although they might contribute to the early increase during development. Our results demonstrate that the functional MC-GC circuit evolves over development in a complex manner that may include both construction and elimination of synapses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.