SynthesisPLoS genetics2011
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.
Synthesis in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder.Molecular psychiatry · 2021Pooled it
- Meta-analysis of genome-wide association from genomic prediction models.Animal genetics · 2016Pooled it
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.PloS one · 2025Article
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.ArXiv · 2024Article
- Why does the X chromosome lag behind autosomes in GWAS findings?PLoS genetics · 2023Article
- Genetic contributions to bipolar disorder: current status and future directions.Psychological medicine · 2021Review
- Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach.Translational psychiatry · 2021Article
- Genetic variants in the bipolar disorder risk locus SYNE1 that affect CPG2 expression and protein function.Molecular psychiatry · 2021Article
- Article
- Polygenic risk for anxiety influences anxiety comorbidity and suicidal behavior in bipolar disorder.Translational psychiatry · 2020Article
- On the diagnostic and neurobiological origins of bipolar disorder.Translational psychiatry · 2020Review
- The genetics of bipolar disorder.Molecular psychiatry · 2020Review
- Detecting significant genotype-phenotype association rules in bipolar disorder: market research meets complex genetics.International journal of bipolar disorders · 2018Article
- Article
- A fast and powerful W-test for pairwise epistasis testing.Nucleic acids research · 2016Article
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- CDH13 and HCRTR2 May Be Associated with Hypersomnia Symptom of Bipolar Depression: A Genome-Wide Functional Enrichment Pathway Analysis.Psychiatry investigation · 2015Article
- Investigating the role of early childhood abuse and HPA axis genes in suicide attempters with bipolar disorder.Psychiatric genetics · 2015Article
- Characteristics of Bipolar I patients grouped by externalizing disorders.Journal of affective disorders · 2015Article
- Structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
38 authors.
Funding
Abstract
Although a highly heritable and disabling disease, bipolar disorder's (BD) genetic variants have been challenging to identify. We present new genotype data for 1,190 cases and 401 controls and perform a genome-wide association study including additional samples for a total of 2,191 cases and 1,434 controls. We do not detect genome-wide significant associations for individual loci; however, across all SNPs, we show an association between the power to detect effects calculated from a previous genome-wide association study and evidence for replication (P = 1.5×10(-7)). To demonstrate that this result is not likely to be a false positive, we analyze replication rates in a large meta-analysis of height and show that, in a large enough study, associations replicate as a function of power, approaching a linear relationship. Within BD, SNPs near exons exhibit a greater probability of replication, supporting an enrichment of reproducible associations near functional regions of genes. These results indicate that there is likely common genetic variation associated with BD near exons (±10 kb) that could be identified in larger studies and, further, provide a framework for assessing the potential for replication when combining results from multiple studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.