ArticlePLoS genetics2011
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 10 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 10 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus.Human molecular genetics · 2022Pooled it
- Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits.Nature genetics · 2016Pooled it
- Trans-ethnic meta-analysis of white blood cell phenotypes.Human molecular genetics · 2014Pooled it
- Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.Diabetes · 2014Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.Human molecular genetics · 2013Pooled it
- Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.Nature communications · 2013Pooled it
- Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.Nature genetics · 2012Pooled it
- Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.Nature genetics · 2012Pooled it
- Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.American journal of human genetics · 2012Pooled it
- Genetic variation in uncontrolled childhood asthma despite ICS treatment.The pharmacogenomics journal · 2016Trial
- Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.PLoS genetics · 2014Trial
- Genetic variation associated with circulating monocyte count in the eMERGE Network.Human molecular genetics · 2013Trial
- Insight into the shared pathogenic link between COVID-19 and pterygium: a systematic bioinformatics analysis with experimental validation.Hereditas · 2025Article
- Article
- Genetic variants associated with white blood cell count amongst individuals with sickle cell disease.British journal of haematology · 2024Article
- Factors associated with genetic markers for rotator cuff disease in patients with atraumatic rotator cuff tears.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals.Blood advances · 2023Article
- Genetic architecture of gene regulation in Indonesian populations identifies QTLs associated with global and local ancestries.American journal of human genetics · 2022Article
- A high-density genome-wide association with absolute blood monocyte count in domestic sheep identifies novel loci.PloS one · 2022Article
Corrections and comments
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Authors and funding
31 authors at 14 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White blood cells (WBCs) mediate immune systems and consist of various subtypes with distinct roles. Elucidation of the mechanism that regulates the counts of the WBC subtypes would provide useful insights into both the etiology of the immune system and disease pathogenesis. In this study, we report results of genome-wide association studies (GWAS) and a replication study for the counts of the 5 main WBC subtypes (neutrophils, lymphocytes, monocytes, basophils, and eosinophils) using 14,792 Japanese subjects enrolled in the BioBank Japan Project. We identified 12 significantly associated loci that satisfied the genome-wide significance threshold of P<5.0×10(-8), of which 9 loci were novel (the CDK6 locus for the neutrophil count; the ITGA4, MLZE, STXBP6 loci, and the MHC region for the monocyte count; the SLC45A3-NUCKS1, GATA2, NAALAD2, ERG loci for the basophil count). We further evaluated associations in the identified loci using 15,600 subjects from Caucasian populations. These WBC subtype-related loci demonstrated a variety of patterns of pleiotropic associations within the WBC subtypes, or with total WBC count, platelet count, or red blood cell-related traits (n = 30,454), which suggests unique and common functional roles of these loci in the processes of hematopoiesis. This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.