ArticlePLoS computational biology2011
Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Activation of silent synapses driven by emerging technologies: mechanisms, disease associations, and prospects for clinical translation.Frontiers in synaptic neuroscience · 2026Review
- Computational Modeling of Extrasynaptic NMDA Receptors: Insights into Dendritic Signal Amplification Mechanisms.International journal of molecular sciences · 2024Article
- Short-term postsynaptic plasticity facilitates predictive tracking in continuous attractors.Frontiers in computational neuroscience · 2023Article
- Role of NMDAR plasticity in a computational model of synaptic memory.Scientific reports · 2021Article
- Regional NeurodegenerationFrontiers in computational neuroscience · 2021Article
- NMDA Receptor Alterations After Mild Traumatic Brain Injury Induce Deficits in Memory Acquisition and Recall.Neural computation · 2021Article
- Article
- Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.The international journal of neuropsychopharmacology · 2015Article
- Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study.PloS one · 2015Article
- Cellular biomechanics of central nervous system injury.Handbook of clinical neurology · 2015Review
- Single-neuron NMDA receptor phenotype influences neuronal rewiring and reintegration following traumatic injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Article
- Approaches and tools for modeling signaling pathways and calcium dynamics in neurons.Journal of neuroscience methods · 2013Review
- N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit.The Journal of biological chemistry · 2012Article
- Dynamic changes in neural circuit topology following mild mechanical injury in vitro.Annals of biomedical engineering · 2012Article
- Synaptic glutamate spillover increases NMDA receptor reliability at the cerebellar glomerulus.Journal of theoretical biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
NMDA receptors (NMDARs) are the major mediator of the postsynaptic response during synaptic neurotransmission. The diversity of roles for NMDARs in influencing synaptic plasticity and neuronal survival is often linked to selective activation of multiple NMDAR subtypes (NR1/NR2A-NMDARs, NR1/NR2B-NMDARs, and triheteromeric NR1/NR2A/NR2B-NMDARs). However, the lack of available pharmacological tools to block specific NMDAR populations leads to debates on the potential role for each NMDAR subtype in physiological signaling, including different models of synaptic plasticity. Here, we developed a computational model of glutamatergic signaling at a prototypical dendritic spine to examine the patterns of NMDAR subtype activation at temporal and spatial resolutions that are difficult to obtain experimentally. We demonstrate that NMDAR subtypes have different dynamic ranges of activation, with NR1/NR2A-NMDAR activation sensitive at univesicular glutamate release conditions, and NR2B containing NMDARs contributing at conditions of multivesicular release. We further show that NR1/NR2A-NMDAR signaling dominates in conditions simulating long-term depression (LTD), while the contribution of NR2B containing NMDAR significantly increases for stimulation frequencies that approximate long-term potentiation (LTP). Finally, we show that NR1/NR2A-NMDAR content significantly enhances response magnitude and fidelity at single synapses during chemical LTP and spike timed dependent plasticity induction, pointing out an important developmental switch in synaptic maturation. Together, our model suggests that NMDAR subtypes are differentially activated during different types of physiological glutamatergic signaling, enhancing the ability for individual spines to produce unique responses to these different inputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.