ArticleMolecular vision2011
Expression of cell proliferation and apoptosis biomarkers in pterygia and normal conjunctiva.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Transcriptomics and network analysis highlight potential pathways in the pathogenesis of pterygium.Scientific reports · 2022Pooled it
- K-ras oncogene mutation in pterygium.Eye (London, England) · 2017Trial
- Autophagy-related pathway dysregulation and apoptosis suppression in pterygium: Role of key biomarkers Beclin-1, ATG5, LC3, p62, and Bcl-2 in pathogenesis and potential nonsurgical targets.The Journal of international medical research · 2026Observational
- Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations.Eye (London, England) · 2024Review
- RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis.Molecular biology reports · 2024Article
- High-throughput screening of transient receptor potential (TRP) channels in pterygium.International ophthalmology · 2024Article
- Synergic Action of Insulin-like Growth Factor-2 and miRNA-483 in Pterygium Pathogenesis.International journal of molecular sciences · 2023Article
- Evaluation of Primary Pterygia on Basis of the Loss of Vertical Length of Plica Semilunaris.Translational vision science & technology · 2021Article
- Expression of p53 and Ki-67 proteins in patients with increasing severity and duration of pterygium.Indian journal of ophthalmology · 2021Article
- Expression and role of specificity protein 1 and collagen I in recurrent pterygial tissues.International journal of ophthalmology · 2021Article
- Analysis of WWOX gene expression and protein levels in pterygium.International ophthalmology · 2020Article
- A novel role for Livin in the response to ultraviolet B radiation and pterygium development.International journal of molecular medicine · 2020Article
- How to minimize pterygium recurrence rates: clinical perspectives.Clinical ophthalmology (Auckland, N.Z.) · 2018Review
- Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium.International journal of immunopathology and pharmacology · 2017Article
- Relationship between expression of cyclooxygenase 2 and neovascularization in human pterygia.Oncotarget · 2017Article
- Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis.Progress in retinal and eye research · 2017Review
- mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3.Scientific reports · 2017Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- Pterygium epithelium abnormal differentiation related to activation of extracellular signal-regulated kinase signaling pathway in vitro.International journal of ophthalmology · 2015Article
- Activated microglia contribute to neuronal apoptosis in Toxoplasmic encephalitis.Parasites & vectors · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the expression of apoptosis and cell proliferation molecules in pterygium tissues of Chinese patients.
methodsThirty-three pterygia were surgically removed using the bare sclera procedure, and 23 normal bulbar conjunctivas were also obtained. Formalin-fixed, paraffin-wax-embedded tissues were analyzed by immunohistochemistry with anti- proliferating cell nuclear antigen (PCNA), K(i)-67 (a proliferating cell marker), mutant p53 (mP53), Bcl-2 associated X-protein (BAX), B-cell lymphoma gene 2 (Bcl-2), and caspase-3 antibodies. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) analysis was used to analyze the apoptotic cells.
resultsOur study revealed that the positive rate of PCNA and K(i)-67 significantly increased in the pterygium samples compared to the normal conjunctiva samples. In the molecules involved in apoptosis, the results showed that the positive rate of Bcl-2 and mP53 significantly increased in the pterygium samples. However, no difference was found between the pterygium and normal conjunctiva samples in the expression of Bax and caspase-3. Through TUNEL analysis, apoptotic cells were seen in the entire width of the epithelial layer in normal conjunctivas but were found mainly confined to the outer layer of the epithelial cells in pterygia.
conclusionsThe finding of high levels of cellular proliferation and low levels of cellular apoptosis in pterygia confirmed that both cell apoptosis and proliferation are known to play an important role in human pterygium pathogenesis.
Indexed as
Identifiers
21738398PMC3130721W80263773What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.