ArticleMolecular vision2011
Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.PloS one · 2013Pooled it
- Pooled it
- Article
- Association of Genetic Polymorphisms in Oxidative Stress and Inflammation Pathways with Glaucoma Risk and Phenotype.Journal of clinical medicine · 2021Article
- Low expression of GSTP1 in the aqueous humour of patients with primary open-angle glaucoma.Journal of cellular and molecular medicine · 2021Article
- Review
- Article
- Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy.Molecular neurobiology · 2016Article
- An Updated Review on the Genetics of Primary Open Angle Glaucoma.International journal of molecular sciences · 2015Review
- Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma.Iranian journal of basic medical sciences · 2014Article
- The Role of Oxidative Stress and Vascular Insufficiency in Primary Open Angle Glaucoma.Clujul medical (1957) · 2014Review
- Genetics of primary open angle glaucoma.Japanese journal of ophthalmology · 2014Review
- Investigating GSTT1 and GSTM1 null genotype as the risk factor of diabetes type 2 retinopathy.Journal of diabetes and metabolic disorders · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association of glutathione S-transferase (GST) GSTM1, GSTT1, and GSTP1 genes with the risk of primary open angle glaucoma (POAG) and clinical features of the disease.
methodsWe conducted a case-control study that included 87 Brazilian patients with POAG and 85 healthy controls matched for age, ethnicity, and sex, whose blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction (PCR) based methods.
resultsThe GSTM1 null polymorphism was significantly more common in the POAG than in the controls group (OR: 2.1, 95% CI: 1.13-3.9; p=0.018). The combined GSTM1 null/GSTT1+ genotype and GSTM1 null/GSTP1 Ile/Val or Val/Val was more prevalent in POAG patients, being a risk factor for POAG (OR: 2.4, 95% CI: 1.16-4.9; p=0.016 and OR: 2.7, 95% CI: 1.07-6.74; p=0.033, respectively). The GSTM1 null/GSTT1+ genotype were associated with higher levels of IOP of both eyes and with more severe defect of the right eye optic nerve. The GSTM1 null/GSTP1 Ile/Val or Val/Val genotypes were associated with higher levels of IOP and more advanced defect of the right eye optic nerve and visual field.
conclusionsWe demonstrate that GSTM1 null polymorphism is associated with POAG in the Brazilian population.
Indexed as
Identifiers
21738397PMC3130720W1575792991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.