ArticleNucleic acids research1990
Binding sites in mammalian genes and viral gene regulatory regions recognized by methylated DNA-binding protein.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Integrative (epi) Genomic Analysis to Predict Response to Androgen-Deprivation Therapy in Prostate Cancer.EBioMedicine · 2018Article
- Transcription factors as readers and effectors of DNA methylation.Nature reviews. Genetics · 2016Review
- The Modulatory Effects of the Polymorphisms in GLA 5'-Untranslated Region Upon Gene Expression Are Cell-Type Specific.JIMD reports · 2015Article
- A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.PloS one · 2011Article
- The g.1170C>T polymorphism of the 5' untranslated region of the human alpha-galactosidase gene is associated with decreased enzyme expression--evidence from a family study.Journal of inherited metabolic disease · 2008Article
- Effect of single-nucleotide polymorphisms of the 5' untranslated region of the human α-galactosidase gene on enzyme activity, and their frequencies in Portuguese caucasians.Journal of inherited metabolic disease · 2008Article
- Collagen alpha1(I) gene (COL1A1) is repressed by RFX family.The Journal of biological chemistry · 2005Article
- Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes.The EMBO journal · 2004Article
- Methylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation.Journal of virology · 2000Article
- Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition.American journal of human genetics · 1999Article
- The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities.Nucleic acids research · 1997Article
- Human alpha-galactosidase A: high plasma activity expressed by the -30G-->A allele.Journal of inherited metabolic disease · 1997Article
- A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity.Molecular and cellular biology · 1996Article
- Increasing binding of a transcription factor immediately downstream of the cap site of a cytomegalovirus gene represses expression.Nucleic acids research · 1995Article
- In vivo estradiol-dependent dephosphorylation of the repressor MDBP-2-H1 correlates with the loss of in vitro preferential binding to methylated DNA.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The effect of histone H1 and DNA methylation on transcription.The Biochemical journal · 1995Article
- The evolution of small DNA viruses of eukaryotes: past and present considerations.Virus genes · 1995Review
- RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.Molecular and cellular biology · 1994Article
- Inactive chromatin spreads from a focus of methylation.Molecular and cellular biology · 1993Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Methylated DNA-binding protein (MDBP), a ubiquitous mammalian protein, recognizes a variety of related DNA sequences. Some of these sequences require methylation of their CpG dinucleotides for binding and others do not. We report that MDBP binds, in a DNA methylation-independent fashion, to two sites in the mouse polyomavirus enhancer, one in the enhancer of the human hepatitis B virus, and to one in the long terminal repeat of equine infectious anemia proviral DNA. We have also found a number of MDBP sites in human and rodent DNAs which bind much better to MDBP when they are methylated at CpG dinucleotides within the recognition site. These include sites at the beginning of the human genes for hypoxanthine phosphoribosyl transferase, HLA-A2, -A3, and -A25 antigens, and alpha-galactosidase A. In the case of methylation-responsive MDBP sites, changes in their methylation status during differentiation or DNA replication could help drive development by modulating transcription.
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