ArticleJournal of orthopaedic trauma2011
Antioxidant therapy attenuates deficient bone fracture repair associated with binge alcohol exposure.
Article in Journal of orthopaedic trauma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- A single acute alcohol intoxication before fracture insult causes long-term elevated systemic RANKL and OPG levels in young adult mice.Scientific reports · 2025Article
- Effect of N-acetylcysteine on fracture healing in rat femoral diaphysis: A histopathological, radiological, and biomechanical analysis.Joint diseases and related surgery · 2025Article
- Episodic alcohol exposure attenuates mesenchymal stem cell chondrogenic differentiation during bone fracture callus formation.Alcoholism, clinical and experimental research · 2022Article
- Bone Marrow Multipotent Mesenchymal Stromal Cells as Autologous Therapy for Osteonecrosis: Effects of Age and Underlying Causes.Bioengineering (Basel, Switzerland) · 2021Review
- Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.Current pathobiology reports · 2020Article
- Ethanol Inhibits Mesenchymal Stem Cell Osteochondral Lineage Differentiation Due in Part to an Activation of Forkhead Box Protein O-Specific Signaling.Alcoholism, clinical and experimental research · 2020Article
- Alcohol-induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment.Animal models and experimental medicine · 2020Article
- Dysfunctional stem and progenitor cells impair fracture healing with age.World journal of stem cells · 2019Review
- N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research.Expert opinion on investigational drugs · 2018Review
- N-Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol-Fed Rats.Alcoholism, clinical and experimental research · 2018Article
- Alcohol exposure decreases osteopontin expression during fracture healing and osteopontin-mediated mesenchymal stem cell migration in vitro.Journal of orthopaedic surgery and research · 2018Article
- Osteogenic Differentiation of Periosteal Cells During Fracture Healing.Journal of cellular physiology · 2017Review
- Alcohol-related deficient fracture healing is associated with activation of FoxO transcription factors in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Alcohol inhibits osteopontin-dependent transforming growth factor-β1 expression in human mesenchymal stem cells.The Journal of biological chemistry · 2015Article
- Ketorolac administration does not delay early fracture healing in a juvenile rat model: a pilot study.Journal of pediatric orthopedics · 2013Article
- Acute alcohol exposure impairs fracture healing and deregulates β-catenin signaling in the fracture callus.Alcoholism, clinical and experimental research · 2012Article
- Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model.Journal of orthopaedic trauma · 2012Article
- The effects of binge-pattern alcohol consumption on orthodontic tooth movement.Dental press journal of orthodonticsArticle
- Exogenous activation of Wnt/β-catenin signaling attenuates binge alcohol-induced deficient bone fracture healing.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesAlcohol consumption is a known risk factor for traumatic injuries of all types and has been shown to produce detrimental effects on bone metabolism. Although the mechanisms responsible for these detrimental effects are not well characterized, oxidative stress from alcohol exposure appears to play a central role. This study was designed to examine the effect of a short-term binge alcohol consumption pattern on fracture repair and the effect of an antioxidant, N-acetylcysteine, on fracture healing after binge alcohol consumption.
methodsOne hundred forty-four adult male Sprague-Dawley rats underwent unilateral closed femur fracture after injection of either saline or alcohol to simulate a binge alcohol cycle. Animals in the antioxidant treatment group received daily N-acetylcysteine after fracture. Femurs were harvested at 1, 2, 4, and 6 weeks after injury and underwent biomechanical testing and histologic analysis.
resultsBinge alcohol administration was associated with significant decreases in biomechanical strength at 1- and 2-week time points with a trend toward decreased strength at 4- and 6-week time points as well. Alcohol-treated animals had less cartilage component within the fracture callus and healed primarily by intramembranous ossification. Administration of N-acetylcysteine in alcohol-treated animals improved biomechanical strength to levels comparable to the control animals and was associated with increased endochondral ossification.
conclusionsOur results indicate that binge alcohol alters the quality of fracture healing after a traumatic injury and that concurrent administration of an antioxidant is able to reverse these effects.
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Registered trials
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