Evidence map›Paper›PMID 21738053›Full record

ArticleJournal of hypertension2011

Clinical significance of nonalbuminuric renal impairment in type 2 diabetes.

Giuseppe Penno, Anna Solini, Enzo Bonora, Cecilia Fondelli, Emanuela Orsi, Gianpaolo Zerbini, Roberto Trevisan, Monica Vedovato, Gabriella Gruden, Franco Cavalot and 6 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04215445 (Effect of Sodium Glucose co Transporter 2), which is not on this map. Cited by 117 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04215445 phase4unknown statusstarted 2019, after this paper: background citation

Effect of Sodium Glucose co Transporter 2 (SGLT2) Inhibition on Optical Coherence Tomography Angiography (OCT-A) Parameters in Diabetic Chronic Kidney Disease (CKD)

Ran2019Enrolled90Registered outcomes3Posted comparisons0ConditionsChronic Kidney Diseases, Diabetes Mellitus, Diabetic RetinopathyArmsempagliflozin 25 mg, OCT-A
PMID 29670074PMID 23042029PMID 25470017PMID 25633683PMID 12028457PMID 16731850PMID 23433046PMID 24026259PMID 26378978PMID 28208170PMID 28340010PMID 28761762other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 3 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Observational
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Observational

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

Giuseppe PennoDepartment of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
Anna Solini
Enzo Bonora
Cecilia Fondelli
Emanuela Orsi
Gianpaolo Zerbini
Roberto Trevisan
Monica Vedovato
Gabriella Gruden
Franco Cavalot
Mauro Cignarelli
Luigi Laviola
Susanna Morano
Antonio Nicolucci
Giuseppe Pugliese
Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
University of Pisa · ITUniversity of Turin · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITMario Negri Sud Foundation · ITOspedale San Giuseppe · ITUniversity of Bari Aldo Moro · ITUniversity of Foggia · ITUniversity of Padua · ITUniversity of Siena · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn type 2 diabetes, prevalence of nonalbuminuric renal impairment is increasing worldwide, though its clinical significance remains unclear. This large-cohort study aimed at evaluating the association of this phenotype with cardiovascular risk factors and other complications.

methodsType 2 diabetic patients from the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study (n = 15,773), visiting consecutively 19 hospital-based Diabetes Clinics in years 2007-2008, were examined. Serum creatinine was assessed by the Jaffe method; albuminuria was measured by immunonephelometry or immunoturbidimetry.

resultsOf patients with renal impairment, as identified by an estimated glomerular filtration rate (eGFR) less than 60 ml/min per 1.73 m², 56.6% were normoalbuminuric, 30.8% were microalbuminuric, and 12.6% were macroalbuminuric. Percentages were similar when GFR was estimated using the more accurate Chronic Kidney Disease Epidemiology Collaboration equation instead of the simplified Modification of Diet in Renal Disease formula, and were independent of age, thus indicating that the increasing prevalence of this phenotype does not reflects misclassification of elderly patients. Nonalbuminuric renal impairment was not associated with HbA(1c) and correlated less strongly with retinopathy and hypertension than albuminuria, either alone or associated with reduced eGFR. It was associated with a higher prevalence of cardiovascular disease (CVD) than albuminuria alone, but lower than albuminuric renal impairment. Female sex correlated with nonalbuminuric renal impairment and male sex with the albuminuric forms.

conclusionsThese data show that type 2 diabetic patients with nonalbuminuric renal impairment exhibit distinct clinical features, suggesting predominance of macroangiopathy as underlying renal pathology, and that this phenotype is associated with significant CVD burden.

Indexed as

Diabetes Mellitus, Type 2FemaleGlomerular Filtration RateHumansKidney DiseasesMale

Identifiers

PMID21738053
OpenAlexW1986549154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.