ArticleJournal of endocrinological investigation2011
Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility.
Article in Journal of endocrinological investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Effect of Testosterone Replacement Therapy on Metabolic Parameters, Prostatic Inflammation Symptoms and Lower Urinary Tract Symptoms (LUTS) in Hypogonadal Obese Subjects Eligible for Bariatric Surgery.
Effectiveness of Testosterone Replacement Therapy (TRT) on Prostatic Gland in Hypogonadal Patients Affected by Benign Prostatic Hyperplasia (BPH) and Metabolic Syndrome (MetS). Florence-PROTEST
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Seminal plasma cytokines in fertile versus infertile men: a systematic review and meta-analysis.Human reproduction update · 2026Pooled it
- BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis.Human reproduction updatePooled it
- Massive Weight Loss Obtained by Bariatric Surgery Affects Semen Quality in Morbid Male Obesity: a Preliminary Prospective Double-Armed Study.Obesity surgery · 2018Trial
- Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health.Molecular nutrition & food research · 2025Review
- Genetically elevated bioavailable testosterone level was associated with the occurrence of benign prostatic hyperplasia.Journal of endocrinological investigation · 2023Article
- Article
- Effects of paternal overnutrition and interventions on future generations.International journal of obesity (2005) · 2022Review
- Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- Metabolic Syndrome and Reproduction.International journal of molecular sciences · 2021Review
- Testosterone, level of the lesion and age are independently associated with prostate volume in men with chronic spinal cord injury.Journal of endocrinological investigation · 2020Article
- Scrotal ultrasonographic findings in obese infertile patients and their correlations to semen and hormonal profile.Turkish journal of urology · 2019Article
- Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing.Journal of visualized experiments : JoVE · 2019Article
- The Disappearing Sperms: Analysis of Reports Published Between 1980 and 2015.American journal of men's health · 2017Review
- Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study.BMC urology · 2017Article
- Paternal obesity: how bad is it for sperm quality and progeny health?Basic and clinical andrology · 2017Article
- Lower urinary tract symptoms, benign prostatic hyperplasia and metabolic syndrome.Nature reviews. Urology · 2016Review
- Abnormalities of Reproductive Function in Male Obesity Before and After Bariatric Surgery-A Comprehensive Review.Obesity surgery · 2015Review
- Urine chemokines indicate pathogenic association of obesity with BPH/LUTS.International urology and nephrology · 2015Article
- Benign prostatic hyperplasia: a new metabolic disease?Journal of endocrinological investigation · 2014Review
- Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.International journal of endocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is associated with a systemic, low-grade inflammatory state. Although the relationship between obesity and semen parameters or prostate diseases has been previously investigated, the association between body mass index (BMI), prostate inflammatory diseases and color- Doppler ultrasound (CDU) of the male genital tract (MGT) has been poorly studied.
aimTo evaluate the association between BMI and CDU features of the MGT, signs and symptoms of prostate inflammation, semen parameters. MATERIALS/SUBJECTS AND
methodsWe studied 222 men seeking medical care for couple infertility. According to the World Health Organization classification, subjects were divided into 3 groups: normal weight (no.=131, BMI=18.5-24.9 kg/m2), overweight (no.=71, BMI=25.0-29.9 kg/m2), obese (no.=20, BMI≥30.0 kg/m2). All patients underwent simultaneous testosterone evaluation and seminal analysis, including interleukin 8 (sIL-8), along with scrotal and transrectal CDU, before and after ejaculation. Prostatitis symptoms were evaluated by National Institutes of Health- Chronic Prostatitis Symptom Index questionnaire.
resultsAfter adjusting for age and testosterone levels, higher BMI was significantly related to higher prostate volume and several CDU features of the prostate, including macro-calcifications, inhomogeneity, higher arterial peak systolic velocity (the latter adjusted also for blood pressure), but not with abnormalities of testis, epididymis, seminal vesicles. Furthermore, higher BMI and BMI class were significantly related to higher sIL-8, a reliable surrogate marker of prostate inflammatory diseases, even after adjustment for age. Conversely, no associations among BMI, clinical symptoms of prostatitis or semen parameters were observed.
conclusionsSubjects with higher BMI might develop CDU and biochemical signs suggestive of prostate inflammation, although not clinically overt.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.