ArticleJournal of endocrinological investigation2012
Relationship between metabolic syndrome and multinodular non-toxic goiter in an inpatient population from a geographic area with moderate iodine deficiency.
Article in Journal of endocrinological investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- The Relationship and Gender Disparity Between Thyroid Nodules and Metabolic Syndrome Components Based on a Recent Nationwide Cross-Sectional Study and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Correlation Between Thyroid Nodules and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Association of Central Obesity and Diabetes with Thyroid Nodules: A 3.2-year Prospective Study in Chinese Adults.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- A Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus.Clinical endocrinology · 2025Article
- Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study.International journal of endocrinology · 2024Article
- Metabolic syndrome is not associated to an increased risk of low bone mineral density in men at risk for osteoporosis.Journal of endocrinological investigation · 2022Article
- Proteomic profiling of thyroid tissue in patients with obesity and benign diffuse goiter.Frontiers in endocrinology · 2022Article
- Non-Toxic Multinodular Goiter: From Etiopathogenesis to Treatment.Sisli Etfal Hastanesi tip bulteni · 2022Review
- Metabolic syndrome is associated to an increased risk of low bone mineral density in free-living women with suspected osteoporosis.Journal of endocrinological investigation · 2021Article
- Development of metabolic syndrome after bilateral total thyroidectomy despite the L-t4 replacement therapy: A prospective study.Turkish journal of surgery · 2018Article
- Article
- Risk factors for silent myocardial ischemia in patients with well-controlled essential hypertension.Internal and emergency medicine · 2017Article
- Metabolic syndrome and nephrolithiasis.Translational andrology and urology · 2014Review
- Iodine status during pregnancy in India and related neonatal and infant outcomes.Public health nutrition · 2014Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and insulin resistance predispose individuals to the development of both metabolic syndrome and non-toxic nodular thyroid diseases.
aimThe aim of this observational, cross-sectional study is to evaluate the relationship between metabolic syndrome and multinodular nontoxic goiter in an inpatient population from a geographic area with moderate iodine deficiency. SUBJECTS AND
methodsWe examined 1422 Caucasian euthyroid inpatients. Thyroid volume was determined by ultrasound of the neck. A fine-needle aspiration biopsy was performed to evaluate single thyroid nodules and dominant nodules ≥15 mm in euthyroid multinodular goiter. The diagnosis of metabolic syndrome was made according to the criteria of the American Heart Association/ National Heart, Lung, and Blood Institute.
resultsOf the sample, 277 patients had clinical evidence of multinodular nontoxic goiter, 461 met the criteria for the diagnosis of metabolic syndrome, and 132 were found to have both conditions. After adjusting for age, gender, body mass index, nicotinism, parity, alcohol intake, thyroid function, and metabolic syndrome- related pharmacological treatment, metabolic syndrome was found to be an independent risk factor for the occurrence of multinodular non-toxic goiter. The relationship between metabolic syndrome and multi nodular non-toxic goiter was apparent in both men and women.
conclusionsIn this study of euthyroid inpatients, we demonstrate that metabolic syndrome is an independent risk factor for the occurrence of multinodular non-toxic goiter in a geographic area with moderate iodine deficiency. We propose that patients meeting the criteria for metabolic syndrome should be screened for the presence of multinodular non-toxic goiter.
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