ArticleJournal of virology1990
Activity of rat Mx proteins against a rhabdovirus.
Article in Journal of virology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 134 citations in OpenAlex.
- Induction and antiviral activity of ferret myxovirus resistance (Mx) protein 1 against influenza A viruses.Scientific reports · 2024Article
- Review
- Review
- Genome-Wide Transcription Analysis of Electroacupuncture Precondition-Induced Ischemic Tolerance on SD Rat With Ischemia-Reperfusion Injury.Frontiers in genetics · 2021Article
- Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV.The Journal of biological chemistry · 2020Article
- Characterization, Expression Pattern and Antiviral Activities of Mx Gene in Chinese Giant Salamander,International journal of molecular sciences · 2020Article
- Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.Journal of virology · 2019Article
- In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.The Journal of experimental medicine · 2017Article
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Insight into alternative approaches for control of avian influenza in poultry, with emphasis on highly pathogenic H5N1.Viruses · 2012Review
- Partial antiviral activities of the Asn631 chicken Mx against newcastle disease virus and vesicular stomatitis virus.Molecular biology reports · 2012Article
- Protective roles of grass carp Ctenopharyngodon idella Mx isoforms against grass carp reovirus.PloS one · 2012Article
- Different physiology of interferon-α/-γ in models of liver regeneration in the rat.Histochemistry and cell biology · 2011Article
- The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity.PloS one · 2010Article
- Article
- Inhibition of a large double-stranded DNA virus by MxA protein.Journal of virology · 2009Article
- The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.Journal of virology · 2009Article
- Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays.Journal of virology · 2008Article
- Bovine and water buffalo Mx2 genes: polymorphism and antiviral activity.Immunogenetics · 2007Article
- Characterization of snakehead rhabdovirus infection in zebrafish (Danio rerio).Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes. One of the rat cDNAs is termed Mx1 because it is most closely related to the mouse Mx1 cDNA and because it codes for a nuclear protein that, like the mouse Mx1 protein, inhibits influenza virus growth. However, this protein differs from mouse Mx1 protein, in that it also inhibits vesicular stomatitis virus (VSV), a rhabdovirus. A second rat cDNA is more closely related to the mouse Mx2 cDNA and directs the synthesis of a cytoplasmic protein that inhibits VSV but not influenza virus. The third rat cDNA codes for a cytoplasmic protein that differs from the second one in only eight positions and has no detectable activity against either virus. These results indicate that rat Mx proteins have antiviral specificities not anticipated from the analysis of the murine Mx1 protein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.