ArticleClinical journal of the American Society of Nephrology : CJASN2011
Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis.International journal of environmental research and public health · 2020Pooled it
- Pooled it
- Chronic Kidney Disease Classification in Systolic Blood Pressure Intervention Trial: Comparison Using Modification of Diet in Renal Disease and CKD-Epidemiology Collaboration Definitions.American journal of nephrology · 2016Trial
- Long-term integrative personalized medicine care in massive brainstem hemorrhage: A CARE-compliant case report.Medicine · 2026Article
- Study variation in estimating Glomerular Filtration Rate (GFR) from serum creatinine, cystatin C, age, and sex.PloS one · 2026Article
- Impact of COVID-19 on chronic kidney disease progression in non-dialysis patients: a retrospective cohort study in Palestine.Annals of medicine · 2025Article
- Off-Label NOACs vs. Antiplatelets in AF-Related Stroke with GFR < 15 mL/Min/1.73 mBiomedicines · 2025Article
- Prevalence and determinants of chronic kidney disease among HIV/AIDS patients in selected governmental hospitals at Addis Ababa, Ethiopia: a retrospective cross-sectional study.BMC infectious diseases · 2025Article
- Predicting renal function using fundus photography: role of confounders.The Korean journal of internal medicine · 2025Article
- Development and validation of a new equation to estimate glomerular filtration rate in Argentinian adults.Scientific reports · 2025Article
- Renal Response Criteria for Clinical Trials in Amyloid Light Chain Amyloidosis.Kidney international reports · 2024Review
- Clinical Implications of Estimating Glomerular Filtration Rate with Different Equations in Heart Failure Patients with Preserved Ejection Fraction.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Article
- Do We Need a New Creatinine-Based Estimated GFR Equation for Kidney Transplant Recipients?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Estimating glomerular filtration rate with new equations: can one size ever fit all?Critical reviews in clinical laboratory sciences · 2023Review
- Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study.BMJ (Clinical research ed.) · 2023Article
- Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations: evidence from three cohorts matched on renal function.Clinical kidney journal · 2022Article
- Acute kidney injury secondary to urinary tract infection in kidney transplant recipients.Scientific reports · 2022Article
- Evaluation of kidney function among people living with HIV initiating antiretroviral therapy in Zambia.PLOS global public health · 2022Article
- Aging and hypertension in kidney function decline: A 10 year population-based study.Frontiers in cardiovascular medicine · 2022Article
- Article
17 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was developed using both CKD and non-CKD patients to potentially replace the Modification of Diet in Renal Disease (MDRD) equation that was derived with only CKD patients. The objective of our study was to compare the accuracy of the MDRD and CKD-EPI equations for estimating GFR in a large group of patients having GFR measurements for diverse clinical indications. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: A cross-sectional study was conducted of patients who underwent renal function assessment for clinical purposes by simultaneous measurements of serum creatinine and estimation of GFR using the MDRD and CKD-EPI equations and renal clearance of iothalamate (n = 5238).
resultsBias compared with measured GFR (mGFR) varied for each equation depending on clinical presentation. The CKD-EPI equation demonstrated less bias than the MDRD equation in potential kidney donors (-8% versus -18%) and postnephrectomy donors (-7% versus -15%). However, the CKD-EPI equation was slightly more biased than the MDRD equation in native CKD patients (6% versus 3%), kidney recipients (8% versus 1%), and other organ recipients (9% versus 3%). Among potential kidney donors, the CKD-EPI equation had higher specificity than the MDRD equation for detecting an mGFR <60 ml/min per 1.73 m(2) (98% versus 94%) but lower sensitivity (50% versus 70%).
conclusionsClinical presentation influences the estimation of GFR from serum creatinine, and neither the CKD-EPI nor MDRD equation account for this. Use of the CKD-EPI equation misclassifies fewer low-risk patients as having reduced mGFR, although it is also less sensitive for detecting mGFR below specific threshold values used to define CKD stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.