ArticleClinical journal of the American Society of Nephrology : CJASN2011
Age-specific association of reduced estimated glomerular filtration rate and albuminuria with all-cause mortality.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Costs and Healthcare Resource Use Associated with Risk of Cardiovascular Morbidity in Patients with Chronic Kidney Disease: Evidence from a Systematic Literature Review.Advances in therapy · 2021Pooled it
- Pooled it
- Using Risk Assessment to Improve Screening for Albuminuria among US Adults without Diabetes.Journal of general internal medicine · 2025Article
- Incretin-based therapy: a new horizon in diabetes management.Journal of diabetes and metabolic disorders · 2024Review
- Effects of Dipeptidyl Peptidase-4 Inhibitor and Angiotensin-Converting Enzyme Inhibitor on Experimental Diabetic Kidney Disease.Laboratory investigation; a journal of technical methods and pathology · 2024Article
- Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study.Clinical kidney journal · 2022Article
- Article
- Prognostic Signature of Chronic Kidney Disease in Advanced Age: Secondary Analysis from the InGAH Study with One-Year Follow-Up.Biomolecules · 2022Article
- Urinary albumin-to-creatinine ratio within normal range and all-cause or cardiovascular mortality among U.S. adults enrolled in the NHANES during 1999-2015.Annals of epidemiology · 2021Article
- Outcomes in Patients with Chronic Kidney Disease After Liver Resection for Hepatocellular Carcinoma.World journal of surgery · 2021Article
- CKD: A Call for an Age-Adapted Definition.Journal of the American Society of Nephrology : JASN · 2019Review
- Hospitalization Risk among Older Adults with Chronic Kidney Disease.American journal of nephrology · 2019Article
- Association between renal function and cardiovascular and all-cause mortality in the community-based elderly population: results from the Specific Health Check and Guidance Program in Japan.Clinical and experimental nephrology · 2018Article
- Chronic Kidney Disease in Panama: Results From the PREFREC Study and National Mortality Trends.Kidney international reports · 2017Article
- Albuminuria and Endothelial Dysfunction in Patients with Non-Diabetic Chronic Kidney Disease.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Reversal of Arterial Stiffness and Maladaptative Arterial Remodeling After Kidney Transplantation.Journal of the American Heart Association · 2017Observational
- Effect of Underlying Renal Disease on Nutritional and Metabolic Profile of Older Adults with Reduced Renal Function.Frontiers in nutrition · 2017Article
- Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study.Journal of the American Heart Association · 2016Article
- An Age-Calibrated Definition of Chronic Kidney Disease: Rationale and Benefits.The Clinical biochemist. Reviews · 2016Article
- The role of cystatin-C in the confirmation of reduced glomerular filtration rate among the oldest old.Archives of medical science : AMS · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesIt has been suggested that reduced estimated GFR (eGFR) among older adults does not necessarily reflect a pathologic phenomenon. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined the association between eGFR and albumin-to-creatinine ratio (ACR) and all-cause mortality stratified by age (45 to 59.9, 60 to 69.9, 70 to 79.9, and ≥80 years) among 24,350 U.S. adults in the population-based REasons for Geographic and Racial Differences in Stroke (REGARDS) study. A spot urine sample was used to calculate ACR, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to calculate eGFR. All-cause mortality was assessed over a median follow-up of 4.5 years.
resultsAmong participants ≥80 years of age (n = 1669), the age, race, gender, and geographic region of residence adjusted hazard ratios (95% confidence intervals) for mortality associated with eGFR levels of 45 to 59.9 and <45 ml/min per 1.73 m(2), versus ≥60 ml/min per 1.73 m(2), were 1.6 (1.3 - 2.1) and 2.2 (1.7 - 2.9), respectively. Also, among participants ≥80 years of age, the hazard ratios for mortality associated with ACR levels of 10 to 29.9, 30 to 299.9, and ≥300 mg/g, versus <10 mg/g, were 1.7 (1.3 - 2.1), 2.5 (1.9 - 3.3), and 5.1 (3.6 - 7.4), respectively. These associations were present after further multivariable adjustment and within the younger age groupings studied.
conclusionsThese data suggest that reduced eGFR and albuminuria confer an increased risk for mortality in all age groups, including adults ≥80 years of age.
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