ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Regional stiffening with aging in tibialis anterior tendons of mice occurs independent of changes in collagen fibril morphology.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Expansion Microscopy reveals changes in cellular and extracellular structures between healthy and perturbed tendons.bioRxiv : the preprint server for biology · 2026Article
- Snhg12 targets miR-199a-5p to regulate osteogenic differentiation of TDSCs via the Fzd4/Wnt/β-catenin pathway.RNA biology · 2025Article
- Structure and function of Achilles and patellar tendons following moderate slow resistance training in young and old men.European journal of applied physiology · 2024Article
- Localization of advanced glycation end-products and their receptor in tendinopathic lesions.Histology and histopathology · 2024Article
- Effect of Aging on Tendon Biology, Biomechanics and Implications for Treatment Approaches.International journal of molecular sciences · 2023Review
- Understanding altered contractile properties in advanced age: insights from a systematic muscle modelling approach.Biomechanics and modeling in mechanobiology · 2023Article
- Lower Macromolecular Content in Tendons of Female Patients with Osteoporosis versus Patients with Osteopenia Detected by Ultrashort Echo Time (UTE) MRI.Diagnostics (Basel, Switzerland) · 2022Article
- Achilles Tendon Ruptures in Middle-Aged Rats Heal Poorly Compared With Those in Young and Old Rats.The American journal of sports medicine · 2022Article
- Effects of aging on the histology and biochemistry of rat tendon healing.BMC musculoskeletal disorders · 2021Article
- Design and validation of a modular micro-robotic system for the mechanical characterization of soft tissues.Acta biomaterialia · 2021Article
- Changes in muscle-tendon unit length-force characteristics following experimentally induced photothrombotic stroke cannot be explained by changes in muscle belly structure.European journal of applied physiology · 2021Article
- Relationship between mechanical properties (shear modulus and viscosity), age, and sex in uninjured Achilles tendons.Translational sports medicine · 2020Article
- Higher BMP Expression in Tendon Stem/Progenitor Cells Contributes to the Increased Heterotopic Ossification in Achilles Tendon With Aging.Frontiers in cell and developmental biology · 2020Article
- Age-related decrease in collagen proton fraction in tibial tendons estimated by magnetization transfer modeling of ultrashort echo time magnetic resonance imaging (UTE-MRI).Scientific reports · 2019Article
- Single finger movements in the aging hand: changes in finger independence, muscle activation patterns and tendon displacement in older adults.Experimental brain research · 2019Article
- The impact of loading, unloading, ageing and injury on the human tendon.The Journal of physiology · 2019Review
- Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging.Cells · 2018Review
- Evaluation of microstructurally motivated constitutive models to describe age-dependent tendon healing.Biomechanics and modeling in mechanobiology · 2018Article
- Aging does not alter tendon mechanical properties during homeostasis, but does impair flexor tendon healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Aging leads to inferior Achilles tendon mechanics and altered ankle function in rodents.Journal of biomechanics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The incidence of tendon degeneration and rupture increases with advancing age. The mechanisms underlying this increased risk remain unknown but may arise because of age-related changes in tendon mechanical properties and structure. Our purpose was to determine the effect of aging on tendon mechanical properties and collagen fibril morphology. Regional mechanical properties and collagen fibril characteristics were determined along the length of tibialis anterior (TA) tendons from adult (8- to 12-mo-old) and old (28- to 30-mo-old) mice. Tangent modulus of all regions along the tendons increased in old age, but the increase was substantially greater in the proximal region adjacent to the muscle than in the rest of the tendon. Overall end-to-end modulus increased with old age at maximum tendon strain (799 ± 157 vs. 1,419 ± 91 MPa) and at physiologically relevant strain (377 ± 137 vs. 798 ± 104 MPa). Despite the dramatic changes in tendon mechanical properties from adulthood to old age, collagen fibril morphology and packing fraction remained relatively constant in all tendon regions examined. Since tendon properties are influenced by their external loading environment, we also examined the effect of aging on TA muscle contractile properties. Maximum isometric force did not differ between the age groups. We conclude that TA tendons stiffen in a region-dependent manner throughout the life span, but the changes in mechanical properties are not accompanied by corresponding changes in collagen fibril morphology or force-generating capacity of the TA muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.