ArticleAmerican journal of human genetics2011
Recent admixture in an Indian population of African ancestry.
Article in American journal of human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Prospective avenues for human population genomics and disease mapping in southern Africa.Molecular genetics and genomics : MGG · 2020Review
- Genetic Diversity and Low Stratification of the Population of the United Arab Emirates.Frontiers in genetics · 2020Article
- Article
- The Genetic Legacy of the Indian Ocean Slave Trade: Recent Admixture and Post-admixture Selection in the Makranis of Pakistan.American journal of human genetics · 2017Article
- Unraveling the Population History of Indian Siddis.Genome biology and evolution · 2017Article
- Population Stratification and Underrepresentation of Indian Subcontinent Genetic Diversity in the 1000 Genomes Project Dataset.Genome biology and evolution · 2016Article
- Evaluation of European coeliac disease risk variants in a north Indian population.European journal of human genetics : EJHG · 2015Article
- Extensive copy number variations in admixed Indian population of African ancestry: potential involvement in adaptation.Genome biology and evolution · 2014Article
- Complex patterns of genomic admixture within southern Africa.PLoS genetics · 2013Article
- Article
- Complex genetic origin of Indian populations and its implications.Journal of biosciences · 2012Review
- Genomic view on the peopling of India.Investigative genetics · 2012Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
Corrections and comments
- Erratum issuedMukhopadhayay, Arijit [corrected to Mukhopadhyay, Arijit]
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification and study of genetic variation in recently admixed populations not only provides insight into historical population events but also is a powerful approach for mapping disease loci. We studied a population (OG-W-IP) that is of African-Indian origin and has resided in the western part of India for 500 years; members of this population are believed to be descendants of the Bantu-speaking population of Africa. We have carried out this study by using a set of 18,534 autosomal markers common between Indian, CEPH-HGDP, and HapMap populations. Principal-components analysis clearly revealed that the African-Indian population derives its ancestry from Bantu-speaking west-African as well as Indo-European-speaking north and northwest Indian population(s). STRUCTURE and ADMIXTURE analyses show that, overall, the OG-W-IPs derive 58.7% of their genomic ancestry from their African past and have very little inter-individual ancestry variation (8.4%). The extent of linkage disequilibrium also reveals that the admixture event has been recent. Functional annotation of genes encompassing the ancestry-informative markers that are closer in allele frequency to the Indian ancestral population revealed significant enrichment of biological processes, such as ion-channel activity, and cadherins. We briefly examine the implications of determining the genetic diversity of this population, which could provide opportunities for studies involving admixture mapping.
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