Evidence map›Paper›PMID 21736960›Full record

ReviewBiochimica et biophysica acta

Mammalian alphaherpesvirus miRNAs.

Igor Jurak, Anthony Griffiths, Donald M Coen

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Viral miRNA regulation of host gene expression.Seminars in cell & developmental biology · 2023
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Viral component of the human genome.Molecular biology · 2017
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Igor JurakDepartment of Biological Chemistry, Harvard Medical School, Boston, MA 02115, USA. igor_jurak@hms.harvard.edu
Anthony Griffiths
Donald M Coen
Harvard University · USTexas Biomedical Research Institute · US

Funding

WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GAUDUIN, MARIE-CLAIRE ELISABETH · 1999 to 2011
$79.1M
VIRAL AND CELLULAR GENES IN HSV LATENCY AND REACTIVATIONP01NS035138 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KNIPE, DAVID M. · 1996 to 2010
$15.0M
MECHANISMS REGULATING HSV TK EXPRESSION DURING INFECTIONR01AI026126 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI COEN, DONALD M · 1988 to 2010
$3.2M
Development of a Vaccine to Protect Monkeys from Herpes B Virus InfectionR21RR026287 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GRIFFITHS, ANTHONY · 2011 to 2011
$219k
NCRR NIH HHS P51 RR013986NCRR NIH HHS R21 RR026287NIAID NIH HHS R01 AI026126NIAID NIH HHS R01 AI26126NINDS NIH HHS P01 NS035138NINDS NIH HHS P01 NS35138
6 · The paper itself

Abstract

Mammalian alphaherpesviruses are major causes of human and veterinary disease. During productive infection, these viruses exhibit complex and robust patterns of gene expression. These viruses also form latent infections in neurons of sensory ganglia in which productive cycle gene expression is highly repressed. Both modes of infection provide advantageous opportunities for regulation by microRNAs. Thus far, published data regarding microRNAs are available for six mammalian alphaherpesviruses. No microRNAs have yet been detected from varicella zoster virus. The five other viruses-herpes simplex viruses-1 and -2, herpes B virus, bovine herpesvirus-1, and pseudorabies virus-representing both genera of mammalian alphaherpesviruses have been shown to express microRNAs. In this article, we discuss these microRNAs in terms of where they are encoded in the viral genome relative to other viral transcripts; whether they are expressed during productive or latent infection; their potential targets; what little is known about their actual targets and functions during viral infection; and what little is known about the interactions of these viruses with the host microRNA machinery. This article is part of a Special Issue entitled: "MicroRNAs in viral gene regulation".

Indexed as

AlphaherpesvirinaeAnimalsGene Expression Regulation, ViralGenome, ViralHerpesvirus 1, HumanHerpesvirus 2, HumanHerpesvirus 3, HumanHumansMicroRNAsVirus LatencyMicroRNAs

Identifiers

PMID21736960
PMCPMC3382970
OpenAlexW2069229237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.