ReviewCurrent pharmaceutical design2011
Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent.
Review in Current pharmaceutical design, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- The road to a long lifespan in the Persian squirrel, a natural model for extended longevity: resisting free radical stress and healthy phospholipids.GeroScience · 2026Article
- Oxidative Stress in an African Ground Squirrel, a Case of Healthy Aging and Reproduction.Antioxidants (Basel, Switzerland) · 2024Article
- The Evolution and Ecology of Oxidative and Antioxidant Status: A Comparative Approach in African Mole-Rats.Antioxidants (Basel, Switzerland) · 2023Article
- Unique Features of the Tissue Structure in the Naked Mole Rat (International journal of molecular sciences · 2022Article
- Sympatric speciation of the spiny mouse from Evolution Canyon in Israel substantiated genomically and methylomically.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Low Cancer Incidence in Naked Mole-Rats May Be Related to Their Inability to Express the Warburg Effect.Frontiers in physiology · 2022Article
- Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies.Antioxidants (Basel, Switzerland) · 2021Review
- DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat.International journal of molecular sciences · 2021Review
- Somatic production of reactive oxygen species does not predict its production in sperm cells across Drosophila melanogaster lines.BMC research notes · 2021Article
- Insights into the Molecular Basis of Genome Stability and Pristine Proteostasis in Naked Mole-Rats.Advances in experimental medicine and biology · 2021Article
- Comparative studies of mitochondrial reactive oxygen species in animal longevity: Technical pitfalls and possibilities.Aging cell · 2019Review
- The Naked Mole Rat: A Unique Example of Positive Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.Oncotarget · 2016Article
- Actin dynamics and cofilin-actin rods in alzheimer disease.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Unraveling the message: insights into comparative genomics of the naked mole-rat.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.Neurochemical research · 2016Article
- Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders.International journal of molecular sciences · 2015Review
- Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity.Biochimica et biophysica acta · 2015Article
- Sympatric speciation revealed by genome-wide divergence in the blind mole rat Spalax.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Characterization, design, and function of the mitochondrial proteome: from organs to organisms.Journal of proteome research · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Reactive oxygen species (ROS), by-products of aerobic metabolism, cause oxidative damage to cells and tissue and not surprisingly many theories have arisen to link ROS-induced oxidative stress to aging and health. While studies clearly link ROS to a plethora of divergent diseases, their role in aging is still debatable. Genetic knock-down manipulations of antioxidants alter the levels of accrued oxidative damage, however, the resultant effect of increased oxidative stress on lifespan are equivocal. Similarly the impact of elevating antioxidant levels through transgenic manipulations yield inconsistent effects on longevity. Furthermore, comparative data from a wide range of endotherms with disparate longevity remain inconclusive. Many long-living species such as birds, bats and mole-rats exhibit high-levels of oxidative damage, evident already at young ages. Clearly, neither the amount of ROS per se nor the sensitivity in neutralizing ROS are as important as whether or not the accrued oxidative stress leads to oxidative-damage-linked age-associated diseases. In this review we examine the literature on ROS, its relation to disease and the lessons gleaned from a comparative approach based upon species with widely divergent responses. We specifically focus on the longest lived rodent, the naked mole-rat, which maintains good health and provides novel insights into the paradox of maintaining both an extended healthspan and lifespan despite high oxidative stress from a young age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.