ArticlePharmacoepidemiology and drug safety2011
Pharmacovigilance for antiretroviral drugs in Africa: lessons from a study in Abidjan, Cote d'Ivoire.
Article in Pharmacoepidemiology and drug safety, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Awareness and Reporting of Antiretroviral Adverse Events Among Clients and Health-Care Providers at a Referral Hospital in Moshi, Northern Tanzania: A Cross-Sectional Study.The East African health research journal · 2019Article
- Observational
- Observational
- Incidence of Severe Neutropenia in HIV-Infected People Starting Antiretroviral Therapy in West Africa.PloS one · 2017Article
- Adverse reactions to antiretroviral therapy: a prevalent concern.Revista panamericana de salud publica = Pan American journal of public health · 2017Article
- Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale.Drug safety · 2016Article
- Article
- Recognition and reporting of suspected adverse drug reactions by surveyed healthcare professionals in Uganda: key determinants.BMJ open · 2014Article
- Antiretroviral treatment and quality of life in Africans living with HIV: 12-month follow-up in Burkina Faso.Journal of the International AIDS Society · 2013Article
- Adverse drug reactions to antiretroviral therapy: prospective study in children in sikasso (mali).The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2012Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAlthough antiretroviral treatment (ART)-related adverse drug reactions (ADR) are documented in industrialised countries, there is no pre-existing surveillance system dedicated to ADR monitoring in most African countries. We assessed knowledge towards pharmacovigilance among ART prescribers and available capacity of HIV clinics to conduct ADR monitoring in Abidjan, Côte d'Ivoire.
methodsA questionnaire was administered to ART prescribers to assess their knowledge towards the occurrence of ADRs. A retrospective ADR survey was also conducted based on a data query of treatment modification/interruptions in three HIV clinics. Clinical monitors went back to medical charts to review and validate the reasons of the treatment modification/interruptions.
resultsOf the 81 ART prescribers interviewed, 25 (31%) declared not grading ADRs and 12 (14.8%) declared notifying ADRs to the national regulatory authorities. Among 5252 adult ART-treated patients who attended the participating clinics in 2008, 599 treatment modifications were identified. Reasons for treatment modification/interruptions identified in the electronic database were documented in the medical charts in 554 cases (92.5%), ADR accounting for 273 cases (45.5%). Toxicity related to ART was graded in only 58 cases (21%) in the medical charts. DISCUSSION: This study describes challenges limiting the implementation of reliable pharmacovigilance activities in HIV clinics in Côte d'Ivoire. The lack of knowledge of ART prescribers concerning ADR grading does not support the spontaneous reporting of ADRs. Using treatment modification/interruptions for ADR monitoring appears feasible, but improvements are needed to respond to key questions related to drug toxicities in the context of ART scale-up in Africa.
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