ArticleEuropean biophysics journal : EBJ2011
Force-velocity relationship for multiple kinesin motors pulling a magnetic bead.
Article in European biophysics journal : EBJ, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Development of electromagnetic tweezers for single-molecule energetics of kinesin.Biophysics and physicobiology · 2026Article
- Multiple kinesins speed up cargo transport in crowded environments by sharing load.Communications biology · 2025Article
- A change point analysis protocol for comparing intracellular transport by different molecular motor combinations.Mathematical biosciences and engineering : MBE · 2021Article
- Diffusive tail anchorage determines velocity and force produced by kinesin-14 between crosslinked microtubules.Nature communications · 2018Article
- Kinesin and Dynein Mechanics: Measurement Methods and Research Applications.Journal of biomechanical engineering · 2018Review
- Ensembles of Bidirectional Kinesin Cin8 Produce Additive Forces in Both Directions of Movement.Biophysical journal · 2017Article
- Tug-of-war of microtubule filaments at the boundary of a kinesin- and dynein-patterned surface.Scientific reports · 2014Article
- Single-molecule fluorescence and in vivo optical traps: how multiple dyneins and kinesins interact.Chemical reviews · 2014Review
- A stochastic model of kinetochore-microtubule attachment accurately describes fission yeast chromosome segregation.The Journal of cell biology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Although the velocity of single kinesin motors against an opposing force F of 0-10 pN is well known, the behavior of multiple kinesin motors working to overcome a larger load is still poorly understood. We have carried out gliding assays in which 3-7 Drosophila kinesin-1 motors moved a microtubule at 200-700 μm/s against a 0-31 pN load at saturating [ATP]. The load F was generated by applying a spatially uniform magnetic field gradient to a superparamagnetic bead attached to the (+) end of the microtubule. When F was scaled by the average number of motors [Symbol: see text]n[Symbol: see text], the force-velocity relationship for multiple motors was similar to the force-velocity relationship for a single motor, supporting a minimal load-sharing model. The velocity distribution at low load has a single mode consistent with rapid fluctuations of n. However, against a load of 2.5-4.7 pN/motor, additional modes appeared at lower velocity. These observations support the Klumpp-Lipowsky model of multimotor transport [Proc Natl Acad Sci USA 102. 17284-17289 (2005)].
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.