ArticleVirchows Archiv : an international journal of pathology2011
Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE).
Article in Virchows Archiv : an international journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Guideline
- Clinical imaging features and outcomes of intrathyroidal thymic carcinoma: an analysis of fourteen patients at a single medical institution.Frontiers in oncology · 2025Article
- Intrathyroid thymic carcinoma: clinicopathological features and whole exome sequencing analysis.Virchows Archiv : an international journal of pathology · 2023Article
- Genomic variation associated with carcinoma showing thymus-like elements (CASTLE) in thyroid gland.Laryngoscope investigative otolaryngology · 2022Article
- Identification of Recurrent TERT Promoter Mutations in Intrathyroid Thymic Carcinomas.Endocrine pathology · 2020Article
- [Ectopic thymic tissue and ectopic thymic tumors].Der Pathologe · 2018Review
- Management and Prognostic Factors for Thyroid Carcinoma Showing Thymus-Like Elements (CASTLE): A Case Series Study.Frontiers in oncology · 2018Article
- Carcinoma showing thymus-like elements of the thyroid gland: report of three cases including one case with breast cancer history.Pathology oncology research : POR · 2015Article
- Extrathyroid carcinoma showing thymus-like differentiation (CASTLE): a new case report and review of the therapeutic role of neck dissection and radiotherapy.World journal of surgical oncology · 2014Review
- KRAS, EGFR, PDGFR-α, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE).Diagnostic pathology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.