ArticleMolecular biology reports2012
Identification and analysis of MC4R polymorphisms and their association with economic traits of Korean cattle (Hanwoo).
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- Rapid SNP genotyping detection method based on PCR-lateral flow dipstick detection technique.Scientific reports · 2025Article
- Innovations in Cattle Breeding Technology: Prospects in the Era of Gene Editing.Animals : an open access journal from MDPI · 2025Review
- A Critical Functional Missense Mutation (T117M) in SheepAnimals : an open access journal from MDPI · 2024Article
- Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle.Veterinary world · 2021Article
- Two co-inherited novel SNPs in the MC4R gene related to live body weight and hormonal assays in Awassi and Arabi sheep breeds of Iraq.Veterinary medicine and science · 2021Article
- Multi-breed genome-wide association studies across countries for electronically recorded behavior traits in local dual-purpose cows.PloS one · 2019Article
- Agouti Signaling Protein and Its Receptors as Potential Molecular Markers for Intramuscular and Body Fat Deposition in Cattle.Frontiers in physiology · 2018Article
- Melanocortin-4 receptor (MC4R) polymorphisms are associated with growth and meat quality traits in sheep.Molecular biology reports · 2014Article
- SNPs of melanocortin 4 receptor (MC4R) associated with body weight in Beagle dogs.Experimental animals · 2014Article
- Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects.Journal of applied genetics · 2013Review
- Association of CAST gene polymorphisms with carcass and meat quality traits in Yanbian cattle of China.Molecular biology reports · 2013Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signaling by the melanocortin-4 receptor (MC4R) is important for mediation the effect of leptin on food intake and energy homeostasis, and is associated with obesity, energy homeostasis and control of feeding behavior. Presently, the bovine MC4R gene was characterized to detect genetic variation at this locus and to relate it to economic traits in Korean cattle (Hanwoo). Five single nucleotide polymorphisms (SNPs) were identified in the coding region (G709A, C927T, C1069G, C1343A, and C1786T). G709A changed amino acid 166 of the MC4R protein from valine to methionine and C1069G changed amino acid 286 of the MC4R protein from leucine to valine. A SNP at C927T significantly influenced the Marbling score, SNP markers C1069G and C1343A significantly affected the Backfat thickness, and the SNP marker C1786T significantly influenced backfat and Marbling score. The MC4R gene may thus be a candidate gene for carcass traits with MC4R SNPs being potentially valuable as genetic markers for economic traits in Hanwoo.
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