ReviewNanoscale2011
Labeling DNA for single-molecule experiments: methods of labeling internal specific sequences on double-stranded DNA.
Review in Nanoscale, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Mechanisms and Strategies for Enhancing DNA Nuclear Entry in Gene Delivery.Cellular and molecular bioengineering · 2026Article
- Advancing Single-Molecule Biophysics: Next-Generation Organic Fluorophores with Tailored Labeling Strategies.Chemical & biomedical imaging · 2025Review
- DNA Visualization Using Fluorescent Proteins.Methods in molecular biology (Clifton, N.J.) · 2023Article
- DNA Labeling Using DNA Methyltransferases.Advances in experimental medicine and biology · 2022Article
- Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.Molecules (Basel, Switzerland) · 2019Review
- Modelling BioNano optical data and simulation study of genome map assembly.Bioinformatics (Oxford, England) · 2018Article
- Ionic Current-Based Mapping of Short Sequence Motifs in Single DNA Molecules Using Solid-State Nanopores.Nano letters · 2017Article
- Efficient modification of λ-DNA substrates for single-molecule studies.Scientific reports · 2017Article
- DNA binding fluorescent proteins for the direct visualization of large DNA molecules.Nucleic acids research · 2016Article
- DNA Labeling Using DNA Methyltransferases.Advances in experimental medicine and biology · 2016Review
- Bacteriophage strain typing by rapid single molecule analysis.Nucleic acids research · 2015Article
- Sequence-specific labeling of nucleic acids and proteins with methyltransferases and cofactor analogues.Journal of visualized experiments : JoVE · 2014Article
- Locked nucleic acid oligomers as handles for single molecule manipulation.Nucleic acids research · 2014Article
- Channeling DNA for optical mapping.Nature biotechnology · 2012Article
- Enzymatically incorporated genomic tags for optical mapping of DNA-binding proteins.Angewandte Chemie (International ed. in English) · 2012Article
- Targeted DNA methylation using an artificially bisected M.HhaI fused to zinc fingers.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review is a practical guide for experimentalists interested in specifically labeling internal sequences on double-stranded (ds) DNA molecules for single-molecule experiments. We describe six labeling approaches demonstrated in a single-molecule context and discuss the merits and drawbacks of each approach with particular attention to the amount of specialized training and reagents required. By evaluating each approach according to criteria relevant to single-molecule experiments, including labeling yield and compatibility with cofactors such as Mg(2+), we provide a simple reference for selecting a labeling method for given experimental constraints. Intended for non-specialists seeking accessible solutions to DNA labeling challenges, the approaches outlined emphasize simplicity, robustness, suitability for use by non-biologists, and utility in diverse single-molecule experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.