ArticleGenetics and molecular biology2011
Anoxia- and hypoxia-induced expression of LDH-A* in the Amazon Oscar, Astronotus crassipinis.
Article in Genetics and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 37 citations in OpenAlex.
- Mitigating Effect of Taurine Combined with Corona Dormancy on Oxidative Stress inInternational journal of molecular sciences · 2025Article
- Combined effects of hypoxia and ammonia-N exposure on the oxygen consumption, glucose metabolism and amino acid metabolism in hybrid grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂).Veterinary research communications · 2024Article
- Potential Involvement of the South American Lungfish Intelectin-2 in Innate-Associated Immune Modulation.International journal of molecular sciences · 2024Article
- Thermoregulatory response in juvenileEcology and evolution · 2024Article
- Effects of acute hypoxia and reoxygenation on oxygen sensors, respiratory metabolism, oxidative stress, and apoptosis in hybrid yellow catfish "Huangyou-1".Fish physiology and biochemistry · 2021Article
- Sevoflurane Postconditioning Reduces Hypoxia/Reoxygenation Injury in Cardiomyocytes via Upregulation of Heat Shock Protein 70.Journal of microbiology and biotechnology · 2021Article
- Identification of Candidate Genes Associated With Hypoxia Tolerance inFrontiers in genetics · 2021Article
- The improved energy metabolism and blood oxygen-carrying capacity for pufferfish, Takifugu fasciatus, against acute hypoxia under the regulation of oxygen sensors.Fish physiology and biochemistry · 2019Article
- Molecular Cloning and Expression Analysis of Lactate Dehydrogenase from the Oriental River PrawnInternational journal of molecular sciences · 2018Article
- Could resistance to lactate accumulation contribute to the better swimming performance ofPeerJ · 2018Article
- Acute hypoxia up-regulates HIF-1α and VEGF mRNA levels in Amazon hypoxia-tolerant Oscar (Astronotus ocellatus).Fish physiology and biochemistry · 2016Article
- Exposure to chronic moderate hypoxia impacts physiological and developmental traits of European sea bass (Dicentrarchus labrax) larvae.Fish physiology and biochemistry · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adaptation or acclimation to hypoxia occurs via the modulation of physiologically relevant genes, such as erythropoietin, transferrin, vascular endothelial growth factor, phosphofructokinase and lactate dehydrogenase A. In the present study, we have cloned, sequenced and examined the modulation of the LDH-A gene after an Amazonian fish species, Astronotus crassipinis (the Oscar), was exposed to hypoxia and anoxia. In earlier studies, we have discovered that adults of this species are extremely tolerant to hypoxia and anoxia, while the juveniles are less tolerant. Exposure of juveniles to acute hypoxia and anoxia resulted in increased LDH-A gene expression in skeletal and cardiac muscles. When exposed to graded hypoxia juveniles show decreased LDH-A expression. In adults, the levels of LDH-A mRNA did not increase in hypoxic or anoxic conditions. Our results demonstrate that, when given time for acclimation, fish at different life-stages are able to respond differently to survive hypoxic episodes.
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