ReviewWorld journal of gastroenterology2011
Familial aggregation in inflammatory bowel disease: is it genes or environment?
Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study.Gut microbes · 2025Article
- Review
- Differences of clinical phenotype between familial and sporadic Crohn's disease in East China.International journal of colorectal disease · 2024Article
- Bidirectional association between inflammatory bowel disease and depression among patients and their unaffected siblings.Journal of gastroenterology and hepatology · 2022Article
- Detecting pathogenic variants in autoimmune diseases using high-throughput sequencing.Immunology and cell biology · 2021Review
- Article
- Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease.World journal of gastroenterology · 2017Review
- Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.Molecular medicine reports · 2017Article
- Abnormalities in endocrine and immune cells are correlated in dextran‑sulfate‑sodium‑induced colitis in rats.Molecular medicine reports · 2017Article
- Susceptibility to Ulcerative Colitis and Genetic Polymorphisms of A251G SOD1 and C-262T CAT.Journal of medical biochemistry · 2016Article
- Genetic sharing and heritability of paediatric age of onset autoimmune diseases.Nature communications · 2015Article
- Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease.World journal of gastroenterology · 2015Review
- Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil.World journal of gastroenterology · 2015Article
- Integrative Therapies and Pediatric Inflammatory Bowel Disease: The Current Evidence.Children (Basel, Switzerland) · 2014Review
- Low hygiene and exposure to infections may be associated with increased risk for ulcerative colitis in a North Indian population.Annals of gastroenterology · 2014Article
- Cell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium.BioMed research international · 2014Review
- Interleukin-33 and inflammatory bowel diseases: lessons from human studies.Mediators of inflammation · 2014Review
- Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.Antioxidants & redox signaling · 2013Review
- Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China.World journal of gastroenterology · 2012Article
- Etiology of inflammatory bowel disease: a unified hypothesis.World journal of gastroenterology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.