ArticleMolecular systems biology2011
Phosphorylation network rewiring by gene duplication.
Article in Molecular systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.Molecular biology of the cell · 2026Article
- Non-redundant roles for paralogous proteins in the yeast glucose-sensing pathway.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary conservation of sequence motifs at sites of protein modification.The Journal of biological chemistry · 2023Article
- Evolutionary biology through the lens of budding yeast comparative genomics.Nature reviews. Genetics · 2017Review
- The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism.G3 (Bethesda, Md.) · 2017Article
- Selection maintains signaling function of a highly diverged intrinsically disordered region.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Plant Actin-Depolymerizing Factors Possess Opposing Biochemical Properties Arising from Key Amino Acid Changes throughout Evolution.The Plant cell · 2017Article
- Article
- An approach for determining and measuring network hierarchy applied to comparing the phosphorylome and the regulome.Genome biology · 2015Article
- Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.PloS one · 2015Article
- Detecting functional divergence after gene duplication through evolutionary changes in posttranslational regulatory sequences.PLoS computational biology · 2014Article
- Article
- Turnover of protein phosphorylation evolving under stabilizing selection.Frontiers in genetics · 2014Review
- Functional divergence and evolutionary turnover in mammalian phosphoproteomes.PLoS genetics · 2014Article
- SH3 interactome conserves general function over specific form.Molecular systems biology · 2013Article
- Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress.Molecular and cellular biology · 2012Article
- Protein abundance is key to distinguish promiscuous from functional phosphorylation based on evolutionary information.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.Open biology · 2012Article
- Where do phosphosites come from and where do they go after gene duplication?International journal of evolutionary biology · 2012Article
- Comparative interaction networks: bridging genotype to phenotype.Advances in experimental medicine and biology · 2012Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Elucidating how complex regulatory networks have assembled during evolution requires a detailed understanding of the evolutionary dynamics that follow gene duplication events, including changes in post-translational modifications. We compared the phosphorylation profiles of paralogous proteins in the budding yeast Saccharomyces cerevisiae to that of a species that diverged from the budding yeast before the duplication of those genes. We found that 100 million years of post-duplication divergence are sufficient for the majority of phosphorylation sites to be lost or gained in one paralog or the other, with a strong bias toward losses. However, some losses may be partly compensated for by the evolution of other phosphosites, as paralogous proteins tend to preserve similar numbers of phosphosites over time. We also found that up to 50% of kinase-substrate relationships may have been rewired during this period. Our results suggest that after gene duplication, proteins tend to subfunctionalize at the level of post-translational regulation and that even when phosphosites are preserved, there is a turnover of the kinases that phosphorylate them.
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