ArticleCell cycle (Georgetown, Tex.)2011
Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins.Cancers · 2025Review
- p27 Cell Cycle Inhibitor and Survival in Luminal-Type Breast Cancer: Gene Ontology, Machine Learning, and Drug Screening Analysis.Journal of breast cancer · 2024Article
- Reciprocal antagonistic regulation of E3 ligases controls ACC synthase stability and responses to stress.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation.Cell death & disease · 2021Article
- Autophagy under glucose starvation enhances protein translation initiation in response to re-addition of glucose in C2C12 myotubes.FEBS open bio · 2020Article
- Siah2 control of T-regulatory cells limits anti-tumor immunity.Nature communications · 2020Article
- The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females.PLoS genetics · 2019Article
- Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.Oncogenesis · 2017Article
- CacyBP/SIP nuclear translocation regulates p27Kip1 stability in gastric cancer cells.World journal of gastroenterology · 2016Article
- SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.Cell cycle (Georgetown, Tex.) · 2015Article
- BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells.Cell death & disease · 2014Article
- PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells.Cancer research · 2014Article
- CacyBP/SIP nuclear translocation induced by gastrin promotes gastric cancer cell proliferation.World journal of gastroenterology · 2014Article
- PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma.Oncoscience · 2014Article
- SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.Oncogene · 2013Article
- Regulators and effectors of Siah ubiquitin ligases.Cell biochemistry and biophysics · 2013Review
- SIAH proteins: critical roles in leukemogenesis.Leukemia · 2013Review
- Decreased skp2 expression is necessary but not sufficient for therapy-induced senescence in prostate cancer.Translational oncology · 2012Article
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8 authors at 1 institution in 1 country.
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Abstract
p27(kip1) has been implicated in cell cycle regulation, functioning as an inhibitor of cyclin-dependent kinase activity. In addition, p27 was also shown to affect cell migration, with accumulation of cytoplasmic p27 associated with tumor invasiveness. However, the mechanism underlying p27 regulation as a cytoplasmic protein is poorly understood. Here we show that glucose starvation induces proteasome-dependent degradation of cytoplasmic p27, accompanied by a decrease in cell motility. We also show that the glucose limitation-induced p27 degradation is regulated through an ubiquitin E3 ligase complex involving Siah1 and SIP/CacyBP. SIP (-/-) embryonic fibroblasts have increased levels of cytosolic p27 and exhibit increased cell motility compared to wild-type cells. These observations suggest that the Siah1/SIP E3 ligase complex regulates cell motility through degradation of p27.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.