ArticleCell cycle (Georgetown, Tex.)2011
JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer.
Article in Cell cycle (Georgetown, Tex.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- JUNB and JUND in Urological Cancers: A Literature Review.Current issues in molecular biology · 2025Review
- Review
- Gadd45g initiates embryonic stem cell differentiation and inhibits breast cell carcinogenesis.Cell death discovery · 2021Article
- Alterations in TGFβ signaling during prostate cancer progression.American journal of clinical and experimental urology · 2021Review
- Identifying Long Non-coding RNA of Prostate Cancer Associated With Radioresponse by Comprehensive Bioinformatics Analysis.Frontiers in oncology · 2020Article
- Essential role of JunD in cell proliferation is mediated via MYC signaling in prostate cancer cells.Cancer letters · 2019Article
- Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2019Article
- The role of NF-κB-mediated JNK pathway in cognitive impairment in a rat model of sleep apnea.Journal of thoracic disease · 2018Article
- Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness.Oncogene · 2017Article
- JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation.The Journal of biological chemistry · 2016Article
- Hepatitis C Virus Increases Free Fatty Acids Absorption and Promotes its Replication Via Down-Regulating GADD45α Expression.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Community Structure Reveals Biologically Functional Modules in MEF2C Transcriptional Regulatory Network.Frontiers in physiology · 2016Article
- Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma.Oncotarget · 2015Article
- Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- GADD45γ induces G2/M arrest in human pharynx and nasopharyngeal carcinoma cells by cucurbitacin E.Scientific reports · 2014Article
- Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation.Arthritis research & therapy · 2014Article
- Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling.Oncotarget · 2013Article
- Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat.BMC systems biology · 2013Article
- Targeting JunD: a potential strategy to counteract hormone-refractory prostate cancer.Cell cycle (Georgetown, Tex.) · 2011Article
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8 authors at 5 institutions in 5 countries.
Funding
Abstract
The AP-1 transcription factor complex has been implicated in a variety of biological processes including cell differentiation, proliferation, apoptosis and oncogenic transformation. We previously established that activation of the AP-1 family member JunD contributes to deregulated expression of the anti-apoptotic IL-6 gene in prostate cancer cells. We now show that inhibition of JunD in prostate cancer cells results in GADD45α- and γ-dependent induction of cell death and inhibition of tumor growth that is mediated at least partially via c-Jun N-terminal kinase (JNK) and p38 kinase activation. Apoptosis induction by dominant negative JunD and JNK and p38 kinase activation are impeded upon knock down of GADD45α and γ expression by small interfering RNA, most vividly demonstrating the central role of GADD45α and γ in JunD-mediated escape of prostate cancer cells from programmed cell death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.