ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
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- The Retinal Basis of Light Aversion in Neonatal Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Go with the FLOW: visualizing spatiotemporal dynamics in optical widefield calcium imaging.Journal of the Royal Society, Interface · 2021Article
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- Retinal ganglion cell interactions shape the developing mammalian visual system.Development (Cambridge, England) · 2020Review
- Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum.BMC genomics · 2019Article
- Gap junctions set the speed and nucleation rate of stage I retinal waves.PLoS computational biology · 2019Article
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- Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword.Frontiers in molecular neuroscience · 2018Review
- Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma.The Journal of clinical investigation · 2017Article
- Article
- Aberrant activity in retinal degeneration impairs central visual processing and relies on Cx36-containing gap junctions.Experimental eye research · 2016Article
- Electrical synapses and the development of inhibitory circuits in the thalamus.The Journal of physiology · 2016Article
- Regulation of Spontaneous Propagating Waves in the Embryonic Mouse Brainstem.Frontiers in neural circuits · 2016Article
- Glutamatergic Retinal Waves.Frontiers in neural circuits · 2016Review
- Ischemic tolerance in pre-myelinated white matter: the role of astrocyte glycogen in brain pathology.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Gap junction coupling synchronizes activity among neurons in adult neural circuits, but its role in coordinating activity during development is less known. The developing retina exhibits retinal waves--spontaneous depolarizations that propagate among retinal interneurons and drive retinal ganglion cells (RGCs) to fire correlated bursts of action potentials. During development, two connexin isoforms, connexin 36 (Cx36) and Cx45, are expressed in bipolar cells and RGCs, and therefore provide a potential substrate for coordinating network activity. To determine whether gap junctions contribute to retinal waves, we compared spontaneous activity patterns using calcium imaging, whole-cell recording, and multielectrode array recording in control, single-knock-out (ko) mice lacking Cx45 and double-knock-out (dko) mice lacking both isoforms. Wave frequency, propagation speed, and bias in propagation direction were similar in control, Cx36ko, Cx45ko, and Cx36/45dko retinas. However, the spontaneous firing rate of individual retinal ganglion cells was elevated in Cx45ko retinas, similar to Cx36ko retinas (Hansen et al., 2005; Torborg and Feller, 2005), a phenotype that was more pronounced in Cx36/45dko retinas. As a result, spatial correlations, as assayed by nearest-neighbor correlation and functional connectivity maps, were significantly altered. In addition, Cx36/45dko mice had reduced eye-specific segregation of retinogeniculate afferents. Together, these findings suggest that although Cx36 and Cx45 do not play a role in gross spatial and temporal propagation properties of retinal waves, they strongly modulate the firing pattern of individual RGCs, ensuring strongly correlated firing between nearby RGCs and normal patterning of retinogeniculate projections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.