ArticleThe American journal of tropical medicine and hygiene2011
Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh.
Article in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Pathogenicity and virulence ofVirulence · 2025Review
- Decrease in Incidence of Diarrhea Due to Cryptosporidium in Bangladeshi Children Is Associated With an Increase in Anti-Cryptosporidium Antibody Avidity.The Journal of infectious diseases · 2025Observational
- Immunity to Cryptosporidium: insights into principles of enteric responses to infection.Nature reviews. Immunology · 2024Review
- UnveilingFrontiers in cellular and infection microbiology · 2024Article
- Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis.The Journal of clinical investigation · 2023Article
- Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium.International journal for parasitology · 2021Article
- Serum IgG Responses to gp15 and gp40 Protein-Derived Synthetic Peptides FromFrontiers in cellular and infection microbiology · 2021Article
- Effect of immunoglobulin G concentration in dairy cow colostrum and calf blood serum onVeterinary world · 2020Article
- Case-Control Study of Cryptosporidium Transmission in Bangladeshi Households.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Application of a salivary immunoassay in a prospective community study of waterborne infections.Water research · 2018Observational
- Lessons Learned from Protective Immune Responses to Optimize Vaccines against Cryptosporidiosis.Pathogens (Basel, Switzerland) · 2017Review
- Asparagine-Linked Glycans ofMolecular & cellular proteomics : MCP · 2017Article
- Serum Anti-Cryptosporidial gp15 Antibodies in Mothers and Children Less than 2 Years of Age in India.The American journal of tropical medicine and hygiene · 2015Article
- Systemic and Mucosal Immune Responses toCurrent tropical medicine reports · 2015Article
- A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.The Lancet. Infectious diseases · 2015Review
- Cryptosporidiosis in HIV/AIDS patients in Kenya: clinical features, epidemiology, molecular characterization and antibody responses.The American journal of tropical medicine and hygiene · 2014Article
- Breast milk parasite-specific antibodies and protection from amebiasis and cryptosporidiosis in Bangladeshi infants: a prospective cohort study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Sirtuins of parasitic protozoa: in search of function(s).Molecular and biochemical parasitology · 2012Review
- Serum IgG responses and seroconversion patterns to Cryptosporidium gp15 among children in a birth cohort in south India.Clinical and vaccine immunology : CVI · 2012Article
- Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh.The American journal of tropical medicine and hygiene · 2012Article
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Authors and funding
12 authors.
Funding
Abstract
Although Cryptospridium hominis is the dominant Cryptosporidium species infecting humans, immune responses to cognate antigens in C. hominis-infected persons have not been reported. We investigated antibody responses to the immunodominant gp15 antigen from C. hominis and C. parvum, in C. hominis-infected Bangladeshi children less than five years of age with diarrhea (cases) and uninfected children with diarrhea (controls). We also investigated polymorphisms in the C. hominis gp15 sequence from cases. Serum IgG responses to gp15 from both species were significantly greater in cases than controls. In spite of polymorphisms in the gp15 sequence, there was a significant correlation between antibody levels to gp15 from both species, indicating cross-reactivity to conserved epitopes. Cases with acute diarrhea had a significantly greater serum IgA response to gp15 compared with those with persistent diarrhea, suggesting that this response may be associated with protection from prolonged disease. These findings support further investigation of gp15 as a vaccine candidate.
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