ArticleJournal of neurophysiology2011
Mechanisms and time course of vocal learning and consolidation in the adult songbird.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 152 citations in OpenAlex.
- A synaptic locus of song learning.Nature · 2026Article
- Gene regulatory co-option drives birdsong neural circuit specialization.bioRxiv : the preprint server for biology · 2026Article
- Estimating the motor exploration in reinforcement learning.iScience · 2026Article
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Reward-driven adaptation of movements requires strong recurrent basal ganglia-cortical loops.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Motor Sequence Learning Involves Better Prediction of the Next Action and Optimization of Movement Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Social context affects sequence modification learning in birdsong.Frontiers in psychology · 2025Article
- Weight Transfer in the Reinforcement Learning Model of Songbird Acquisition.bioRxiv : the preprint server for biology · 2024Article
- How neural systems transform synaptic plasticity into behavioral learning.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Female calls promote song learning in male juvenile zebra finches.Nature communications · 2024Article
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Resilience of A Learned Motor Behavior After Chronic Disruption of Inhibitory Circuits.bioRxiv : the preprint server for biology · 2024Article
- Recall tempo of Hebbian sequences depends on the interplay of Hebbian kernel with tutor signal timing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Goal-directed vocal planning in a songbird.eLife · 2024Article
- Daily singing of adult songbirds functions to maintain song performance independently of auditory feedback and age.Communications biology · 2024Article
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- Anterior forebrain pathway in parrots is necessary for producing learned vocalizations with individual signatures.Current biology : CB · 2023Article
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27 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In songbirds, the basal ganglia outflow nucleus LMAN is a cortical analog that is required for several forms of song plasticity and learning. Moreover, in adults, inactivating LMAN can reverse the initial expression of learning driven via aversive reinforcement. In the present study, we investigated how LMAN contributes to both reinforcement-driven learning and a self-driven recovery process in adult Bengalese finches. We first drove changes in the fundamental frequency of targeted song syllables and compared the effects of inactivating LMAN with the effects of interfering with N-methyl-d-aspartate (NMDA) receptor-dependent transmission from LMAN to one of its principal targets, the song premotor nucleus RA. Inactivating LMAN and blocking NMDA receptors in RA caused indistinguishable reversions in the expression of learning, indicating that LMAN contributes to learning through NMDA receptor-mediated glutamatergic transmission to RA. We next assessed how LMAN's role evolves over time by maintaining learned changes to song while periodically inactivating LMAN. The expression of learning consolidated to become LMAN independent over multiple days, indicating that this form of consolidation is not completed over one night, as previously suggested, and instead may occur gradually during singing. Subsequent cessation of reinforcement was followed by a gradual self-driven recovery of original song structure, indicating that consolidation does not correspond with the lasting retention of changes to song. Finally, for self-driven recovery, as for reinforcement-driven learning, LMAN was required for the expression of initial, but not later, changes to song. Our results indicate that NMDA receptor-dependent transmission from LMAN to RA plays an essential role in the initial expression of two distinct forms of vocal learning and that this role gradually wanes over a multiday process of consolidation. The results support an emerging view that cortical-basal ganglia circuits can direct the initial expression of learning via top-down influences on primary motor circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.