ArticleJournal of neurophysiology2011
GABA(B)-mediated inhibition of multiple modes of glutamate release in the nucleus of the solitary tract.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant.Brain : a journal of neurology · 2025Article
- Hindbrain ghrelin and liver-expressed antimicrobial peptide 2, ligands for growth hormone secretagogue receptor, bidirectionally control food intake.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Gamma-Aminobutyric Acid Transporters in the Nucleus Tractus Solitarii Regulate Inhibitory and Excitatory Synaptic Currents That Influence Cardiorespiratory Function.Frontiers in physiology · 2021Article
- Extensive Inhibitory Gating of Viscerosensory Signals by a Sparse Network of Somatostatin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Understanding diverse TRPV1 signaling - an update.F1000Research · 2019Review
- Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents.PloS one · 2017Article
- Distinct Calcium Sources Support Multiple Modes of Synaptic Release from Cranial Sensory Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat.Journal of chemical neuroanatomy · 2016Article
- Vanilloids selectively sensitize thermal glutamate release from TRPV1 expressing solitary tract afferents.Neuropharmacology · 2016Article
- Temperature differentially facilitates spontaneous but not evoked glutamate release from cranial visceral primary afferents.PloS one · 2015Article
- External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1.Journal of neurophysiology · 2014Article
- The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade.Physiological reports · 2014Article
- Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons.Journal of neurophysiology · 2014Article
- H₂O₂ induces delayed hyperexcitability in nucleus tractus solitarii neurons.Neuroscience · 2014Article
- Proposed toxic and hypoxic impairment of a brainstem locus in autism.International journal of environmental research and public health · 2013Article
- TRPV1-dependent regulation of synaptic activity in the mouse dorsal motor nucleus of the vagus nerve.Frontiers in neuroscience · 2013Article
- The unsilent majority-TRPV1 drives "spontaneous" transmission of unmyelinated primary afferents within cardiorespiratory NTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- Opioids inhibit visceral afferent activation of catecholamine neurons in the solitary tract nucleus.Neuroscience · 2012Article
- Peptide and lipid modulation of glutamatergic afferent synaptic transmission in the solitary tract nucleus.Frontiers in neuroscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the caudal portions of the solitary tract (ST) nucleus, primary sensory afferents fall into two broad classes based on the expression of transient receptor potential vanilloid type 1 (TRPV1) receptors. Both afferent classes (TRPV1+/-) have indistinguishable glutamate release mechanisms for ST-evoked excitatory postsynaptic currents (EPSCs). However, TRPV1+ terminals release additional glutamate from a unique, TRPV1-operated vesicle pool that is temperature sensitive and facilitated by ST activity to generate asynchronous EPSCs. This study tested whether presynaptic γ-aminobutyric acid (GABA)(B) receptors inhibit both the evoked and TRPV1-operated release mechanisms on second-order ST nucleus neurons. In horizontal slices, shocks activated single ST axons and evoked the time-invariant (latency jitter <200 μs), glutamatergic EPSCs, which identified second-order neurons. Gabazine eliminated GABA(A) responses in all recordings. The GABA(B) agonist baclofen inhibited the amplitude of ST-EPSCs from both TRPV1+ and TRPV1- afferents with a similar EC(50) (∼1.2 μM). In TTX, GABA(B) activation decreased miniature EPSC (mEPSC) rates but not amplitudes, suggesting presynaptic actions downstream from terminal excitability. With calcium entry through voltage-activated calcium channels blocked by cadmium, baclofen reduced mEPSC frequency, indicating that GABA(B) reduced vesicle release by TRPV1-dependent calcium entry. GABA(B) activation also reduced temperature-evoked increases in mEPSC frequency, which relies on TRPV1. Our studies indicate that GABA(B) G protein-coupled receptors are uniformly distributed across all ST primary afferent terminals and act at multiple stages of the excitation-release cascades to suppress both action potential-triggered and TRPV1-coupled glutamate transmission pathways. Moreover, the segregated release cascades within TRPV1+ ST primary afferents represent independent, potential targets for differential modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.