ArticleThe Journal of clinical endocrinology and metabolism2011
The economics of improving medication adherence in osteoporosis: validation and application of a simulation model.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medication adherence and health care utilization in pediatric chronic illness: a systematic review.Pediatrics · 2013Pooled it
- Economic evaluation of a population-based osteoporosis intervention for outpatients with non-traumatic non-hip fractures: the "Catch a Break" 1i [type C] FLS.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Potential cost-effectiveness for using patient decision aids to guide osteoporosis treatment.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- The potential economic benefits of improved postfracture care: a cost-effectiveness analysis of a fracture liaison service in the US health-care system.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Article
- Challenges in implementing and maintaining osteoporosis therapy.International journal of women's health · 2014Review
- Comparison of prescribing and adherence patterns of anti-osteoporotic medications post-admission for fragility type fracture in an urban teaching hospital and a rural teaching hospital in Ireland between 2005 and 2008.Irish journal of medical science · 2013Article
- Health technology assessment in osteoporosis.Calcified tissue international · 2013Review
- Medication (re)fill adherence measures derived from pharmacy claims data in older Americans: a review of the literature.Drugs & aging · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
contextAdherence to osteoporosis treatment is low. Although new therapies and behavioral interventions may improve medication adherence, questions are likely to arise regarding their cost-effectiveness.
objectiveOur objectives were to develop and validate a model to simulate the clinical outcomes and costs arising from various osteoporosis medication adherence patterns among women initiating bisphosphonate treatment and to estimate the cost-effectiveness of a hypothetical intervention to improve medication adherence.
designWe constructed a computer simulation using estimates of fracture rates, bisphosphonate treatment effects, costs, and utilities for health states drawn from the published literature. Probabilities of transitioning on and off treatment were estimated from administrative claims data. SETTING AND PATIENTS: Patients were women initiating bisphosphonate therapy from the general community.
interventionWe evaluated a hypothetical behavioral intervention to improve medication adherence.
main outcome measuresChanges in 10-yr fracture rates and incremental cost-effectiveness ratios were evaluated.
resultsA hypothetical intervention with a one-time cost of $250 and reducing bisphosphonate discontinuation by 30% had an incremental cost-effectiveness ratio (ICER) of $29,571 per quality-adjusted life year in 65-yr-old women initiating bisphosphonates. Although the ICER depended on patient age, intervention effectiveness, and intervention cost, the ICERs were less than $50,000 per quality-adjusted life year for the majority of intervention cost and effectiveness scenarios evaluated. Results were sensitive to bisphosphonate cost and effectiveness and assumptions about the rate at which intervention and treatment effects decline over time.
conclusionsOur results suggests that behavioral interventions to improve osteoporosis medication adherence will likely have favorable ICERs if their efficacy can be sustained.
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