ArticleBMC molecular biology2011
CGGBP1 regulates cell cycle in cancer cells.
Article in BMC molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Molecular cargo of small EVs from NSCLC patient BALF and plasma: unveiling their role in airway inflammation and immune regulation in a novel human 3D bronchial model.Cell communication and signaling : CCS · 2025Article
- The CGG triplet repeat binding protein 1 counteracts R-loop induced transcription-replication stress.EMBO reports · 2025Article
- The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression.BMC genomic data · 2024Article
- CGGBP1-dependent CTCF-binding sites restrict ectopic transcription.Cell cycle (Georgetown, Tex.) · 2021Article
- An immunochemistry-based screen for chemical inhibitors of DNA-protein interactions and its application to human CGGBP1.BMC cancer · 2020Article
- CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity.BMC genetics · 2020Article
- CGGBP1 regulates CTCF occupancy at repeats.Epigenetics & chromatin · 2019Article
- Identification of Key Genes Affecting Results of Hyperthermia in Osteosarcoma Based on Integrative ChIP-Seq/TargetScan Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs.Cell cycle (Georgetown, Tex.) · 2016Article
- Defining the role of the CGGBP1 protein in FMR1 gene expression.European journal of human genetics : EJHG · 2016Article
- CGGBP1 mitigates cytosine methylation at repetitive DNA sequences.BMC genomics · 2015Article
- Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action.Chemical science · 2015Article
- Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.International journal of clinical and experimental pathology · 2015Article
- CGGBP1--an indispensable protein with ubiquitous cytoprotective functions.Upsala journal of medical sciences · 2015Review
- Polymorphisms in twelve candidate genes are associated with growth, muscle lipid profile and meat quality traits in eleven European cattle breeds.Molecular biology reports · 2014Article
- Regulating Pol III transcription to change Pol II transcriptome.Cell cycle (Georgetown, Tex.) · 2014Article
- A new twist on cell growth control.Cell cycle (Georgetown, Tex.) · 2014Article
- CGGBP1 phosphorylation constitutes a telomere-protection signal.Cell cycle (Georgetown, Tex.) · 2014Article
- NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.International journal of molecular sciences · 2012Article
- miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma.BMC cancer · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCGGBP1 is a CGG-triplet repeat binding protein, which affects transcription from CGG-triplet-rich promoters such as the FMR1 gene and the ribosomal RNA gene clusters. Earlier, we reported some previously unknown functions of CGGBP1 in gene expression during heat shock stress response. Recently we had found CGGBP1 to be a cell cycle regulatory midbody protein required for normal cytokinetic abscission in normal human fibroblasts, which have all the cell cycle regulatory mechanisms intact.
resultsIn this study we explored the role of CGGBP1 in the cell cycle in various cancer cell lines. CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase. CGGBP1 depletion also increased the expression of cell cycle regulatory genes CDKN1A and GAS1, associated with reductions in histone H3 lysine 9 trimethylation in their promoters. By combining RNA interference and genetic mutations, we found that the role of CGGBP1 in cell cycle involves multiple mechanisms, as single deficiencies of CDKN1A, GAS1 as well as TP53, INK4A or ARF failed to rescue the G0/G1 arrest caused by CGGBP1 depletion.
conclusionsOur results show that CGGBP1 expression is important for cell cycle progression through multiple parallel mechanisms including the regulation of CDKN1A and GAS1 levels.
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