ArticleGenome biology2011
Genome sequence and global sequence variation map with 5.5 million SNPs in Chinese rhesus macaque.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Genomic Evidence for the Complex Evolutionary History of Macaques (Genus Macaca).Journal of molecular evolution · 2024Article
- DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species.Evolutionary applications · 2024Article
- Genomic Copy Number Variation Study of Nine Macaca Species Provides New Insights into Their Genetic Divergence, Adaptation, and Biomedical Application.Genome biology and evolution · 2020Article
- MACSNVdb: a high-quality SNV database for interspecies genetic divergence investigation among macaques.Database : the journal of biological databases and curation · 2020Article
- Comparative genome-wide survey of single nucleotide variation uncovers the genetic diversity and potential biomedical applications among six Macaca species.International journal of molecular sciences · 2018Article
- Population genomics of wild Chinese rhesus macaques reveals a dynamic demographic history and local adaptation, with implications for biomedical research.GigaScience · 2018Article
- Genomic Tools for the Use of Nonhuman Primates in Translational Research.ILAR journal · 2017Review
- RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque.Molecular biology and evolution · 2016Article
- Multicopy gene family evolution on primate Y chromosomes.BMC genomics · 2016Article
- Selectively Constrained RNA Editing Regulation Crosstalks with piRNA Biogenesis in Primates.Molecular biology and evolution · 2015Article
- Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates.PLoS genetics · 2015Article
- Harnessing cross-species alignment to discover SNPs and generate a draft genome sequence of a bighorn sheep (Ovis canadensis).BMC genomics · 2015Article
- Whole-genome sequencing of tibetan macaque (Macaca Thibetana) provides new insight into the macaque evolutionary history.Molecular biology and evolution · 2014Article
- Evolutionary interrogation of human biology in well-annotated genomic framework of rhesus macaque.Molecular biology and evolution · 2014Article
- Killer whale nuclear genome and mtDNA reveal widespread population bottleneck during the last glacial maximum.Molecular biology and evolution · 2014Article
- Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species.Genome biology · 2014Article
- Major histocompatibility complex class I haplotype diversity in Chinese rhesus macaques.G3 (Bethesda, Md.) · 2013Article
- In transition: primate genomics at a time of rapid change.ILAR journal · 2013Review
- Old world monkeys and new age science: the evolution of nonhuman primate systems virology.ILAR journal · 2013Review
- Evolutionary survey of druggable protein targets with respect to their subcellular localizations.Genome biology and evolution · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRhesus macaque (Macaca mulatta) is the most widely used nonhuman primate animal in biomedical research. A global map of genetic variations in rhesus macaque is valuable for both evolutionary and functional studies.
resultsUsing next-generation sequencing technology, we sequenced a Chinese rhesus macaque genome with 11.56-fold coverage. In total, 96% of the reference Indian macaque genome was covered by at least one read, and we identified 2.56 million homozygous and 2.94 million heterozygous SNPs. We also detected a total of 125,150 structural variations, of which 123,610 were deletions with a median length of 184 bp (ranging from 25 bp to 10 kb); 63% of these deletions were located in intergenic regions and 35% in intronic regions. We further annotated 5,187 and 962 nonsynonymous SNPs to the macaque orthologs of human disease and drug-target genes, respectively. Finally, we set up a genome-wide genetic variation database with the use of Gbrowse.
conclusionsGenome sequencing and construction of a global sequence variation map in Chinese rhesus macaque with the concomitant database provide applicable resources for evolutionary and biomedical research.
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