Evidence map›Paper›PMID 21732950›Full record

ArticleJournal of medical primatology2011

Increased inherent intestinal granzyme B expression may be associated with SIV pathogenesis in Asian non-human primates.

A T Hutchison, J E Schmitz, C J Miller, K J Sastry, P N Nehete, A M Major, A A Ansari, N Tatevian, D E Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Granzyme BGut microbes
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

A T HutchisonUniversity of Texas Health Science Center-Medical School at Houston, Division of Infectious Diseases, Department of Internal Medicine, Houston, 77030, USA. Alexander.T.Hutchison@uth.tmc.edu
J E Schmitz
C J Miller
K J Sastry
P N Nehete
A M Major
A A Ansari
N Tatevian
D E Lewis
The University of Texas Health Science Center at Houston · USThe University of Texas MD Anderson Cancer Center · USBeth Israel Deaconess Medical Center · USEmory University · USTexas Children's Hospital · USUniversity of California, Davis · US

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
ANERGY, APOPTOSIS AND CD28 IN CD8+ T CELLS DURING AIDSR37AI036682 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LEWIS, DOROTHY E. · 2000 to 2010
$3.7M
Immune control of SIVagm replication in vivoR01AI065335 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHMITZ, JOERN E. · 2006 to 2009
$2.9M
TRAINING PROGRAM FOR CLINICAL RESEARCH ON AIDST32AI007456 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI SHEARER, WILLIAM THOMAS · 1992 to 2012
$2.8M
SIVSMMPBJ SUPERANTIGEN AND VIRAL PATHOGENICITYR29AI036628 · NIAID · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHEN, ZHENG W · 1995 to 1999
–
NIAID NIH HHS AI36628NIAID NIH HHS P30 AI036211NIAID NIH HHS R01 AI065335NIAID NIH HHS R37 AI036682NIAID NIH HHS R37 AI36211NIAID NIH HHS T32 AI007456
6 · The paper itself

Abstract

backgroundUnlike Asian non-human primates, chronically SIV-infected African non-human primates (NHP) display a non-pathogenic disease course. The different outcomes may be related to the development of an SIV-mediated breach of the intestinal mucosa in the Asian species that is absent in the African animals.

methodsTo examine possible mechanisms that could lead to the gut breach, we determined whether the colonic lamina propria (LP) of SIV-naïve Asian monkeys contained more granzyme B (GrB) producing CD4 T cells than did that of the African species. GrB is a serine protease that may disrupt mucosal integrity by damaging tight junction proteins.

resultsWe found that the colonic LP of Asian NHP contain more CD4(+) /GrB(+) cells than African NHP. We also observed reduced CD4 expression on LP T cells in African green monkeys.

conclusionBoth phenotypic differences could protect against SIV-mediated damage to the intestinal mucosa and could lead to future therapies in HIV(+) humans.

Indexed as

Cercocebus atysChlorocebus aethiopsMacacaAnimalsCD4 Lymphocyte CountCD4-Positive T-LymphocytesColonDisease Models, AnimalGranzymesHumansIntestinal MucosaMembrane ProteinsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSpecies Specificityendotoxin binding proteinsGranzymesMembrane Proteins

Identifiers

PMID21732950
PMCPMC3193863
OpenAlexW1674322370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.