ReviewJournal of cardiovascular translational research2011
SPECT imaging for detecting coronary artery disease and determining prognosis by noninvasive assessment of myocardial perfusion and myocardial viability.
Review in Journal of cardiovascular translational research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- Complex CTO Revascularization in Patients with Ischemic Heart Failure and Reduced Ejection Fraction: An Illustrative Case Series.Journal of clinical medicine · 2026Article
- Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management.Chembiochem : a European journal of chemical biology · 2026Review
- Illuminating Cardiac Remodeling: Insights From [Journal of the American Heart Association · 2025Article
- Left Ventricular Wall Motion as an Additional Valuable Parameter in Diabetic Patients with Normal Myocardial Perfusion Imaging.Current radiopharmaceuticals · 2025Article
- Clinical and imaging characteristics of cardiac magnetic resonance presenting with myocardial infarction with non-obstructive coronary arteries in China.Journal of cardiothoracic surgery · 2022Article
- The Relationship Between Coronary Dominance and Positive Results in Myocardial Perfusion Imaging.Cureus · 2022Article
- Monte Carlo Simulation and Reconstruction: Assessment of Myocardial Perfusion Imaging of Tracer Dynamics With Cardiac Motion Due to Deformation and Respiration Using Gamma Camera With Continuous Acquisition.Frontiers in cardiovascular medicine · 2022Article
- Incremental value of myocardial wall motion and thickening to perfusion alone by gated SPECT myocardial perfusion imaging for viability assessment in patients with ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Radionuclide, magnetic resonance and computed tomography imaging in European round back slugs (Arionidae) and leopard slugs (Limacidae).Scientific reports · 2021Article
- Surgical revascularization in stable coronary artery disease with ventricular dysfunction: a single-center cohort study.American journal of cardiovascular disease · 2021Article
- Validation of cadmium-zinc-telluride camera for measurement of left ventricular systolic performance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Significance of inferior wall ischemia in non-dominant right coronary artery anatomy.World journal of cardiology · 2017Article
- Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration.Physics in medicine and biology · 2015Article
- Prediction of 14-year outcomes in patients with a limited exercise capacity: Utility of dobutamine myocardial perfusion imaging in a high-risk population.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- An overview on development and application of an experimental platform for quantitative cardiac imaging research in rabbit models of myocardial infarction.Quantitative imaging in medicine and surgery · 2014Review
- Association of biomarkers of lipid modification with functional and morphological indices of coronary stenosis severity in stable coronary artery disease.Journal of cardiovascular translational research · 2013Article
- Outcomes of middle cardiac vein arterialization via internal mammary/thoracic artery anastomosis.PloS one · 2013Article
- Sudden cardiac death after repair of anomalous origin of left coronary artery from right sinus of Valsalva with an interarterial course : Case report and review of the literature.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2012Article
- CT fractional flow reserve: the next level in non-invasive cardiac imaging.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2012Article
- The Association of Alanine Aminotransferase Levels With Myocardial Perfusion Imaging and Cardiovascular Morbidity.Journal of cardiovascular pharmacology and therapeuticsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basic knowledge of active and passive transport mechanisms for concentrating monovalent cations in myocardial cells led to the investigation of the application of radioisotopes of potassium, thallium, rubidium, and ammonia to the in vivo noninvasive assessment of regional myocardial perfusion and viability utilizing gamma camera or positron emission tomographic (PET) imaging technology. Subsequently, technetium-99m (Tc-99m)-labeled isonitriles (sestamibi and tetrofosmin), which bind to mitochondrial membranes, emerged as superior imaging agents with single photon emission tomography (SPECT) imaging. When any of these imaging agents are injected intravenously during either exercise or pharmacologic stress, myocardial defects in tracer uptake represent either abnormal regional flow reserve or myocardial scar reflecting of coronary artery disease (CAD). The major clinical indications for stress SPECT or PET myocardial perfusion imaging are for detection of CAD as the cause of chest pain and risk stratification for prognostication. Patients with normal stress myocardial perfusion scans have an excellent prognosis with <1.0% annual rate future annual death or nonfatal infarction. The greater the extent and severity of ischemic perfusion defects (defects seen on stress images but improve on resting images), the greater the subsequent death or infarction rate during follow-up. Rest imaging alone is performed for determination of myocardial viability in patients with CAD and severe left ventricular dysfunction. Myocardial segments showing >50% uptake compared to normal uptake have a better long-term outcome with revascularization than with medical therapy with enhanced left ventricular function and improved survival. Other applications of SPECT imaging include the evaluation of cardiac sympathetic function, assessment of myocardial metabolism in health and disease, and molecular imaging of coronary atherosclerosis and myocardial stem cell therapy.
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Registered trials
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