Evidence map›Paper›PMID 21732194›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2011

Genetic determinants for intramuscular fat content and water-holding capacity in mice selected for high muscle mass.

Stefan Kärst, Riyan Cheng, Armin O Schmitt, Hyuna Yang, Fernando Pardo Manuel de Villena, Abraham A Palmer, Gudrun A Brockmann

Abstract read
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
  6. Article
  7. Fine mapping on chromosome 13q32-34 and brain expression analysis implicates MYO16 in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefan KärstDepartment for Crop and Animal Sciences, Humboldt-Universität zu Berlin, Invalidenstraße 42, 10115 Berlin, Germany. stefan.kaerst@agrar.hu-berlin.de
Riyan Cheng
Armin O Schmitt
Hyuna Yang
Fernando Pardo Manuel de Villena
Abraham A Palmer
Gudrun A Brockmann

Funding

Systems Genetic Analysis of Methamphetamine's Motivational Effects in a Mouse AILR01DA021336 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2006 to 2015
$4.0M
Genome-wide association studies in outbred miceR01GM097737 · NIGMS · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2011 to 2014
$1.9M
FINDING GENES THAT CAUSE QLT FOR FEAR LEARNING AND ANXIETYR01MH079103 · NIMH · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2007 to 2011
$1.9M
Novel Methods to Map Stimulant QTLs in Advanced Intercross LinesR21DA024845 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2008 to 2009
$422k
NIDA NIH HHS R01 DA021336NIDA NIH HHS R21 DA024845NIDA NIH HHS R21DA024845NIGMS NIH HHS R01 GM097737NIMH NIH HHS R01 MH079103
6 · The paper itself

Abstract

Intramuscular fat content and water-holding capacity are important traits in livestock as they influence meat quality, nutritive value of the muscle, and animal health. As a model for livestock, two inbred lines of the Berlin Muscle Mouse population, which had been long-term selected for high muscle mass, were used to identify genomic regions affecting intramuscular fat content and water-holding capacity. The intramuscular fat content of the Musculus longissimus was on average 1.4 times higher in BMMI806 than in BMMI816 mice. This was accompanied by a 1.5 times lower water-holding capacity of the Musculus quadriceps in BMMI816 mice. Linkage analyses with 332 G(3) animals of reciprocal crosses between these two lines revealed quantitative trait loci for intramuscular fat content on chromosome 7 and for water-holding capacity on chromosome 2. In part, the identified loci coincide with syntenic regions in pigs in which genetic effects for the same traits were found. Therefore, these muscle-weight-selected mouse lines and the produced intercross populations are valuable genetic resources to identify genes that could also contribute to meat quality in other species.

Indexed as

Body WaterQuantitative Trait LociAnimalsBody Weights and MeasuresFatsFemaleMaleMiceMuscle, SkeletalPhenotypeFats

Identifiers

PMID21732194
PMCPMC3318964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.