ReviewMammalian genome : official journal of the International Mammalian Genome Society2011
The emerging role for rat models in gene discovery.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- Article
- Isolation of muscle stem cells from rat skeletal muscles.Stem cell research · 2020Article
- Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus.Scientific reports · 2019Article
- Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.BMC genomics · 2017Article
- Comprehensive coverage of cardiovascular disease data in the disease portals at the Rat Genome Database.Physiological genomics · 2016Article
- Rat Breeding Parameters According to Floor Space Available in Cage.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease.Database : the journal of biological databases and curation · 2015Article
- A simple, quantitative method using alginate gel to determine rat colonic tumor volume in vivo.Comparative medicine · 2014Article
- Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics.Neuropharmacology · 2014Article
- Comparison of 2 rat breeding schemes using conventional caging.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
- Rat mir-155 generated from the lncRNA Bic is 'hidden' in the alternate genomic assembly and reveals the existence of novel mammalian miRNAs and clusters.RNA (New York, N.Y.) · 2013Article
- Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface.Placenta · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Rat models have been used for many decades to study physiological and pathophysiological mechanisms. Prior to the release of the rat genome and new technologies for targeting gene manipulation, the rat had been the underdog in the genomics era, despite the abundance of physiological data compared to the mouse. The overarching goal of biomedical research is to improve health and advance medical science. Translating human disease gene discovery and validation in the rat, through the use of emerging technologies and integrated tools and databases, is providing power to understand the genetics, environmental influences, and biology of disease. In this review we briefly outline the rat models, bioinformatics tools, and technologies that are changing the landscape of translational research. The strategies used to translate disease traits to genes to function, and, ultimately, to improve human health is discussed. Finally, our perspective on how rat models will continue to positively impact biomedical research is provided.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.