ArticleInternational journal of clinical pharmacy2011
Gender and use of hypnotics or sedatives in old age: a nationwide register-based study.
Article in International journal of clinical pharmacy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Psychotropic Drug Use and Associated Factors Among Acutely Admitted Older People: A Cross-Sectional Study of a Clinical Sample.Drugs - real world outcomes · 2024Article
- Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015.Environmental science & technology · 2023Article
- The distribution of disease in the Republic of Suriname - A pharmacoepidemiological analysis using the claims database of the State Health Foundation of the year 2017.Journal of public health and epidemiology · 2021Article
- Gender Differences in Medication Use: A Drug Utilization Study Based on Real World Data.International journal of environmental research and public health · 2020Article
- Observational
- Drug burden index to define the burden of medicines in older adults with intellectual disabilities: An observational cross-sectional study.British journal of clinical pharmacology · 2018Observational
- Differences in drug use between men and women: an Italian cross sectional study.BMC women's health · 2017Article
- Observational
- Increased use of hypnotics in individuals with celiac disease: a nationwide case-control study.BMC gastroenterology · 2015Article
- Article
- Risk of hip fracture among older people using anxiolytic and hypnotic drugs: a nationwide prospective cohort study.European journal of clinical pharmacology · 2014Article
- Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness.Sleep disorders · 2014Review
- Treatment of multiple sclerosis in Germany: an analysis based on claims data of more than 30,000 patients.International journal of clinical pharmacy · 2013Article
- Differences in drug utilisation between men and women: a cross-sectional analysis of all dispensed drugs in Sweden.BMJ open · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether gender is associated with use of hypnotics or sedatives and with different types of hypnotics or sedatives in older people after adjustment for age, socioeconomic status (i.e., education) and co-morbidity (i.e., number of other drugs).
settingSweden Method We conducted a register-based analysis of data on gender, age, dispensed drugs, and education from people aged 75-89 years registered in the Swedish Prescribed Drug Register between July and October 2005 (n = 645,429).
main outcome measureThe hypnotic or sedative drug classes were benzodiazepines, benzodiazepine related drugs (i.e., Z-drugs) and other types of hypnotics or sedatives. The individual hypnotics or sedatives were nitrazepam, flunitrazepam, triazolam, zopiclone, zolpidem, clomethiazole and propiomazine.
resultsIn the total study population, 27.1% of the women and 18.1% of the men were dispensed at least one hypnotic or sedative drug. The logistic regression analyses of those who used hypnotics or sedatives (n = 151,700) revealed that women were more likely than men to use benzodiazepines (adjusted OR = 1.11; 95% CI 1.07-1.14) and benzodiazepine related drugs (adjusted OR = 1.14; 95% CI 1.12-1.17), whereas men were more likely to use other types of hypnotics or sedatives (adjusted OR = 0.69; 95% CI 0.67-0.71). Among the individual hypnotics or sedatives, the strongest associations with gender was found for nitrazepam (adjusted OR = 1.19; 95% CI 1.14-1.25 for women compared with men), zolpidem (adjusted OR = 1.18; 95% CI 1.16-1.21), clomethiazole (adjusted OR = 0.48; 95% CI 0.46-0.51) and propiomazine (adjusted OR = 0.77; 95% CI 0.75-0.79).
conclusionUse of hypnotics or sedatives in old age seems to be related to female gender. Also, among elderly users of hypnotics or sedatives, women appear to be more likely to use benzodiazepines and benzodiazepine related drugs than men. The explanation to these gender differences merits further investigation.
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