ArticleExpert opinion on drug discovery2011
Homeostatic bioenergetic network regulation - a novel concept to avoid pharmacoresistance in epilepsy.
Article in Expert opinion on drug discovery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Tetrahedral framework nucleic acids: Nanokeys unlocking a new era of precision biomedicine.Journal of advanced research · 2026Review
- Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review.Metabolic brain disease · 2024Review
- Brain energy metabolism: A roadmap for future research.Journal of neurochemistry · 2024Review
- Adenosine and Ketogenic Treatments.Journal of caffeine and adenosine research · 2020Review
- Dynamic Changes of Astrocytes and Adenosine Signaling in Rat Hippocampus in Post-status Epilepticus Model of Epileptogenesis.Cellular and molecular neurobiology · 2018Article
- Neural Signaling Metabolites May Modulate Energy Use in Hibernation.Neurochemical research · 2017Review
- Environmental Enrichment Mitigates Detrimental Cognitive Effects of Ketogenic Diet in Weanling Rats.Journal of molecular neuroscience : MN · 2016Article
- Ketogenic diet sensitizes glucose control of hippocampal excitability.Journal of lipid research · 2014Article
- The role of T-type calcium channel genes in absence seizures.Frontiers in neurology · 2014Review
- Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Adenosine receptors and epilepsy: current evidence and future potential.International review of neurobiology · 2014Review
- Role of adenosine in status epilepticus: a potential new target?Epilepsia · 2013Review
- Adenosine and autism: a spectrum of opportunities.Neuropharmacology · 2013Review
- Purines and neuronal excitability: links to the ketogenic diet.Epilepsy research · 2012Review
- Defining clinico-neuropathological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis.Brain pathology (Zurich, Switzerland) · 2012Review
- Caffeine prevents acute mortality after TBI in rats without increased morbidity.Experimental neurology · 2012Article
- The nervous system and metabolic dysregulation: emerging evidence converges on ketogenic diet therapy.Frontiers in neuroscience · 2012Article
- Article
- The relationship between the neuromodulator adenosine and behavioral symptoms of autism.Neuroscience letters · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
introductionDespite epilepsy being one of the most prevalent neurological disorders, one third of all patients with epilepsy cannot adequately be treated with available antiepileptic drugs. One of the significant causes for the failure of conventional pharmacotherapeutic treatment is the development of pharmacoresistance in many forms of epilepsy. The problem of pharmacoresistance has called for the development of new conceptual strategies that improve future drug development efforts. AREAS COVERED: A thorough review of the recent literature on pharmacoresistance in epilepsy was completed and select examples were chosen to highlight the mechanisms of pharmacoresistance in epilepsy and to demonstrate how those mechanistic findings might lead to improved treatment of pharmacoresistant epilepsy. The reader will gain a thorough understanding of pharmacoresistance in epilepsy and an appreciation of the limitations of conventional drug development strategies. EXPERT OPINION: Conventional drug development efforts aim to achieve specificity of symptom control by enhancing the selectivity of drugs acting on specific downstream targets; this conceptual strategy bears the undue risk of development of pharmacoresistance. Modulation of homeostatic bioenergetic network regulation is a novel conceptual strategy to affect whole neuronal networks synergistically by mobilizing multiple endogenous biochemical and receptor-dependent molecular pathways. In our expert opinion we conclude that homeostatic bioenergetic network regulation might thus be used as an innovative strategy for the control of pharmacoresistant seizures. Recent focal adenosine augmentation strategies support the feasibility of this strategy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.