ArticleExpert opinion on drug discovery2011
Green Tea Polyphenols in drug discovery - a success or failure?
Article in Expert opinion on drug discovery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor.Scientific reports · 2022Article
- Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis.Bioorganic & medicinal chemistry letters · 2022Article
- Analysis of Mercury Content in Various Types of Tea (International journal of environmental research and public health · 2022Article
- Microbial Diversity and Characteristics of Kombucha as Revealed by Metagenomic and Physicochemical Analysis.Nutrients · 2021Article
- Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice.Scientific reports · 2020Article
- Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point.Neurochemical research · 2019Review
- The acute effect of a single dose of green tea on the quality and quantity of tears in normal eye subjects.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits.Molecular genetics & genomic medicine · 2017Review
- Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer.International journal of molecular sciences · 2017Review
- Design, development, and characterization of lipid nanocarriers-based epigallocatechin gallate delivery system for preventive and therapeutic supplementation.Drug design, development and therapy · 2016Article
- Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Frontiers in pharmacology · 2016Review
- Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.Journal of molecular modeling · 2015Article
- A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans.Journal of virology · 2014Article
- Glutamate dehydrogenase: structure, allosteric regulation, and role in insulin homeostasis.Neurochemical research · 2014Review
- The structure and allosteric regulation of mammalian glutamate dehydrogenase.Archives of biochemistry and biophysics · 2012Review
- Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.The Journal of biological chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Green tea is made from unfermented dried leaves from Camellia sinensis and has been consumed by humans for thousands of years. For nearly as long, it has been used as a folk remedy for a wide array of diseases. More recently, a large number of in-vitro and in-vivo scientific studies have supported this ancient contention that the polyphenols from green tea can provide a number of health benefits. Since these compounds are clearly safe for human consumption and ubiquitous in the food supply, they are highly attractive as lead compounds for drug discovery programs. However, as drugs, they are far from optimum. They are relatively unstable, poorly absorbed, and readily undergo a number of metabolic transformations by intestinal microbiota and human enzymes. Further, since these compounds target a wide array of biological systems, in-vivo testing is rather difficult since effects on alternative pathways need to be carefully eliminated. The purpose of this review is to discuss some of the challenges and benefits of pursuing this family of compounds for drug discovery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.