ArticleMarine drugs2011
Heterofucan from Sargassum filipendula induces apoptosis in HeLa cells.
Article in Marine drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Pharmacological Properties and Phytochemical Profile ofMarine drugs · 2026Review
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- Seaweeds in the Oncology Arena: Anti-Cancer Potential of Fucoidan as a Drug-A Review.Molecules (Basel, Switzerland) · 2022Review
- Extraction of Fucoidan fromACS omega · 2021Article
- Pharmacological and natural products diversity of the brown algae genusRSC advances · 2020Review
- Fucoidan Inhibition of Osteosarcoma Cells Is Species and Molecular Weight Dependent.Marine drugs · 2020Article
- The Yemeni Brown AlgaeBioMed research international · 2020Article
- Article
- Fucoidan and cancer: a multifunctional molecule with anti-tumor potential.Marine drugs · 2015Review
- Methanolic extracts from brown seaweeds Dictyota cilliolata and Dictyota menstrualis induce apoptosis in human cervical adenocarcinoma HeLa cells.Molecules (Basel, Switzerland) · 2015Article
- Polypeptide Fraction from Arca subcrenata Induces Apoptosis and G2/M Phase Arrest in HeLa Cells via ROS-Mediated MAPKs Pathways.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Anticancer and cancer preventive properties of marine polysaccharides: some results and prospects.Marine drugs · 2013Article
- Freshwater plants synthesize sulfated polysaccharides: heterogalactans from Water Hyacinth (Eicchornia crassipes).International journal of molecular sciences · 2012Article
- Fucose-containing sulfated polysaccharides from brown seaweeds inhibit proliferation of melanoma cells and induce apoptosis by activation of caspase-3 in vitro.Marine drugs · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated l-fucose. Heterofucan SF-1.5v was extracted from the brown seaweed Sargassum filipendula by proteolytic digestion followed by sequential acetone precipitation. This fucan showed antiproliferative activity on Hela cells and induced apoptosis. However, SF-1.5v was not able to activate caspases. Moreover, SF-1.5v induced glycogen synthase kinase (GSK) activation, but this protein is not involved in the heterofucan SF-1.5v induced apoptosis mechanism. In addition, ERK, p38, p53, pAKT and NFκB were not affected by the presence of SF-1.5v. We determined that SF-1.5v induces apoptosis in HeLa mainly by mitochondrial release of apoptosis-inducing factor (AIF) into cytosol. In addition, SF-1.5v decreases the expression of anti-apoptotic protein Bcl-2 and increased expression of apoptogenic protein Bax. These results are significant in that they provide a mechanistic framework for further exploring the use of SF-1.5v as a novel chemotherapeutics against human cervical cancer.
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