ArticleDose-response : a publication of International Hormesis Society2011
Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug.
Article in Dose-response : a publication of International Hormesis Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Escalated Oxycodone Self-Administration Is Associated with Activation of Specific Gene Networks in the Rat Dorsal Striatum.International journal of molecular sciences · 2025Article
- Regional Analysis of the Brain Transcriptome in Mice Bred for High and Low Methamphetamine Consumption.Brain sciences · 2019Article
- Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine.Neurotoxicology · 2018Article
- Effect of three different regimens of repeated methamphetamine on rats' cognitive performance.Cognitive processing · 2018Article
- Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress.Oxidative medicine and cellular longevity · 2018Review
- The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment.Frontiers in molecular neuroscience · 2018Review
- Does Repeated Methamphetamine Exposure at Different Regimens Cause Parkinsonian-Like Behavior in Rats?Iranian journal of pharmaceutical research : IJPR · 2018Article
- Article
- Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system.Experimental neurology · 2015Article
- Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor.The international journal of neuropsychopharmacology · 2014Article
- Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors.Frontiers in behavioral neuroscience · 2014Article
- Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.Synapse (New York, N.Y.) · 2013Article
- Electroacupuncture stimulation of the brachial plexus trunk on the healthy side promotes brain-derived neurotrophic factor mRNA expression in the ischemic cerebral cortex of a rat model of cerebral ischemia/reperfusion injury.Neural regeneration research · 2012Article
- Article
- Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.Journal of addiction & preventionArticle
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10 authors.
Funding
Abstract
Methamphetamine (METH) is a toxic drug of abuse, which can cause significant decreases in the levels of monoamines in various brain regions. However, animals treated with progressively increasing doses of METH over several weeks are protected against the toxic effects of the drug. In the present study, we tested the possibility that this pattern of METH injections might be associated with transcriptional changes in the rat striatum, an area of the brain which is known to be very sensitive to METH toxicity and which is protected by METH preconditioning. We found that the presence and absence of preconditioning followed by injection of large doses of METH caused differential expression in different sets of striatal genes. Quantitative PCR confirmed METH-induced changes in some genes of interest. These include small heat shock 27 kD proteins 1 and 2 (HspB1 and HspB2), brain derived neurotrophic factor (BDNF), and heme oxygenase-1 (Hmox-1). Our observations are consistent with previous studies which have reported that ischemic or pharmacological preconditioning can cause reprogramming of gene expression after lethal ischemic insults. These studies add to the growing literature on the effects of preconditioning on the brain transcriptome.
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