ArticleInternational journal of molecular sciences2011
Fabrication and intermolecular interactions of silk fibroin/hydroxybutyl chitosan blended nanofibers.
Article in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings.Scientific reports · 2024Article
- MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1.Signal transduction and targeted therapy · 2023Article
- Review
- Ovarian Cell Encapsulation in an Enzymatically Crosslinked Silk-Based Hydrogel with Tunable Mechanical Properties.Gels (Basel, Switzerland) · 2021Article
- Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?International journal of molecular sciences · 2021Article
- Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair.Frontiers in bioengineering and biotechnology · 2020Article
- Electrospun SF/PLCL nanofibrous membrane: a potential scaffold for retinal progenitor cell proliferation and differentiation.Scientific reports · 2015Article
- Dual drug release electrospun core-shell nanofibers with tunable dose in the second phase.International journal of molecular sciences · 2014Article
- Fast disintegrating quercetin-loaded drug delivery systems fabricated using coaxial electrospinning.International journal of molecular sciences · 2013Article
- The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways.International journal of molecular sciences · 2012Review
- Properties and biocompatibility of chitosan and silk fibroin blend films for application in skin tissue engineering.TheScientificWorldJournal · 2012Article
- Will silk fibroin nanofiber scaffolds ever hold a useful place in Translational Regenerative Medicine?International journal of burns and trauma · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The native extracellular matrix (ECM) is composed of a cross-linked porous network of multifibril collagens and glycosaminoglycans. Nanofibrous scaffolds of silk fibroin (SF) and hydroxybutyl chitosan (HBC) blends were fabricated using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and trifluoroacetic acid (TFA) as solvents to biomimic the native ECM via electrospinning. Scanning electronic microscope (SEM) showed that relatively uniform nanofibers could be obtained when 12% SF was blended with 6% HBC at the weight ratio of 50:50. Meanwhile, the average nanofibrous diameter increased when the content of HBC in SF/HBC blends was raised from 20% to 100%. Fourier transform infrared spectra (FTIR) and (13)C nuclear magnetic resonance (NMR) showed SF and HBC molecules existed in hydrogen bonding interactions but HBC did not induce conformation of SF transforming from random coil form to β-sheet structure. X-ray diffraction (XRD) confirmed the different structure of SF/HBC blended nanofibers from both SF and HBC. Thermogravimetry-Differential thermogravimetry (TG-DTG) results demonstrated that the thermal stability of SF/HBC blend nanofibrous scaffolds was improved. The results indicated that the rearrangement of HBC and SF molecular chain formed a new structure due to stronger hydrogen bonding between SF and HBC. These electrospun SF/HBC blended nanofibers may provide an ideal tissue engineering scaffold and wound dressing.
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