ArticleIndian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology2011
The relationship between serum lipid levels and the risk of oral cancer.
Article in Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Serum lipid alterations in oral squamous cell carcinoma and oral potentially malignant disorders: A systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study.BMC oral health · 2023Pooled it
- Lipid homeostasis dysregulation in oral cancer drives metabolic reprogramming and offers novel diagnostic and therapeutic opportunities.Discover oncology · 2025Review
- Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never-Smoking Adults.Head & neck · 2025Article
- The Prognostic Value of Preoperative Total Cholesterol in Surgically Treated Oral Cavity Cancer.Biomedicines · 2024Article
- Comparative Study of Serum Lipid Profile in Tobacco Addicts, Tobacco Non-addicts and Head-Neck Malignancy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- The evaluation of serum lipid profile and apolipoprotein C-1 in the Iranian patients of Oral Squamous Cell Carcinoma.BioMedicine · 2022Article
- Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview.Frontiers in oncology · 2022Review
- Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.PLoS genetics · 2021Article
- Serum Paraoxonase-1-Related Variables and Lipoprotein Profile in Patients with Lung or Head and Neck Cancer: Effect of Radiotherapy.Antioxidants (Basel, Switzerland) · 2019Article
- Comparative Evaluation of Serum Lipid Profile in Patients with Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with that of Control Subjects: A Case Control Study.Journal of pharmacy & bioallied sciences · 2017Article
- The Efficacy of Oral Nutritional Intervention in Malnourished Cancer Patients: a Systemic Review.Clinical nutrition research · 2016Review
- Alteration of Lipid Profile in Patients with Head and Neck Malignancy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2016Article
- Early detection and personalized treatment in oral cancer: the impact of omics approaches.Molecular cytogenetics · 2016Review
- Impact of cholesterol on disease progression.BioMedicine · 2015Article
- Estimation of serum lipids in patients with Oral Submucous Fibrosis in India.Journal of clinical and experimental dentistry · 2014Article
- Serum lipid profile in patients with oral cancer and oral precancerous conditions.Dental research journal · 2014Article
- Serum lipid profile in oral precancer and cancer: a diagnostic or prognostic marker?Journal of international oral health : JIOH · 2014Article
- Should variation of serum lipid levels be considered a risk factor for the development of basal cell carcinoma?Advanced biomedical research · 2014Article
- Evaluation and correlation of serum lipid profile in oral and gastrointestinal cancer patients.Journal of international oral health : JIOH · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipids are the major cell membrane components essential for various biological functions including cell growth and division for the maintenance of cell integrity of normal and malignant tissues. The changes in lipid profile have long been associated with cancer. Hypocholesterolemia has been observed in patients with cancers of various organs. Therefore, a causative relationship might exist between plasma lipid levels and oral cancer patients.
aimThe objective of this study was to investigate the alterations and clinical significance of plasma lipid profiles in untreated head and neck cancer patients. MATERIALS AND
methodsA total of 30 subjects (25 oral cancer patients and 5 controls) were included. Fasting blood lipid profile including cholesterol (C), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were evaluated using spectrophotometric kits, with CHOD PAP technique. The values were then statistically analyzed using analysis of variance (ANOVA) and post hoc methods.
resultsThe levels of total lipids, cholesterol and HDL were significantly lower in oral cancer patients as compared to controls, but LDL and VLDL values were not significant.
conclusionAn inverse relationship was found between the lipid levels and the occurrence of oral cancer. Hence, the lower plasma lipid status may be a useful indicator to detect the initial changes seen in neoplastic process.
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