Evidence map›Paper›PMID 21731035›Full record

SynthesisEuropean journal of clinical nutrition2011

Vitamin D and type 2 diabetes: a systematic review.

J Mitri, M D Muraru, A G Pittas

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 26 pooled it
37.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 26 syntheses or guidelines pooled it, 568 citations in OpenAlex.

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  10. Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2020
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

J MitriDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA.
M D Muraru
A G Pittas
Tufts Medical Center · USCarney Hospital · US

Funding

TUFTS CLINICAL AND TRANSLATION SCIENCE INSTITUTE (UL1): BPCAUL1RR025752 · NCRR · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2008 to 2011
$17.6M
Vitamin D and Calcium Homeostasis in Relation to Type 2 DiabetesR01DK076092 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2006 to 2015
$4.1M
Vitamin D Status in Relation to Incident Type 2 Diabetes and Cardiometabolic RiskR01DK079003 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2008 to 2010
$957k
NCRR NIH HHS UL1 RR025752NIDDK NIH HHS R01 DK076092NIDDK NIH HHS R01 DK079003NIDDK NIH HHS R01DK76092NIDDK NIH HHS R01DK79003
6 · The paper itself

Abstract

BACKGROUND/

objectivesVitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes.

methodsWe performed a systematic review of English-language studies using MEDLINE through February 2011. Longitudinal cohort studies reporting associations between vitamin D status and incident type 2 diabetes, and randomized controlled trials (RCTs) of vitamin D supplementation, were included. Study characteristics and results were extracted, and study quality was assessed.

resultsA total of 8 observational cohort studies and 11 RCTs were included. In meta-analyses of observational studies, vitamin D intake>500 international units (IU)/day decreased the risk of type 2 diabetes by 13% compared with vitamin D intake<200 IU/day. Individuals with the highest vitamin D status (>25 ng/ml) had a 43% lower risk of developing type 2 diabetes (95% confidence interval 24, 57%) compared with those in the lowest group (<14 ng/ml). In post hoc analyses from eight trials among participants with normal glucose tolerance at baseline and in three small underpowered (n=32-62) trials of patients with established type 2 diabetes, there was no effect of vitamin D supplementation on glycemic outcomes. In two trials among patients with baseline glucose intolerance, vitamin D supplementation improved insulin resistance.

conclusionsVitamin D may play a role in type 2 diabetes; however, to better define the role of vitamin D in the development and progression of type 2 diabetes, high-quality observational studies and RCTs that measure blood 25-hydroxyvitamin D concentration and clinically relevant glycemic outcomes are needed.

Indexed as

Dietary SupplementsBlood GlucoseCalcium, DietaryData Interpretation, StatisticalDiabetes Mellitus, Type 2Glucose IntoleranceHumansInsulin ResistanceMeta-Analysis as TopicRandomized Controlled Trials as TopicVitamin DVitaminsBlood GlucoseCalcium, DietaryVitamin DVitamins

Identifiers

PMID21731035
PMCPMC4066381
OpenAlexW2032405414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.