ArticleThe American journal of sports medicine2011
Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II.
Article in The American journal of sports medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Short-Term Contact Kinematic Changes and Longer-Term Biochemical Changes in the Cartilage After ACL Reconstruction: A Pilot Study.Annals of biomedical engineering · 2018Trial
- Preventing osteoarthritis after anterior cruciate ligament injury: The case for targeting pre-osteoarthritis illness.Osteoarthritis and cartilage · 2026Article
- A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention.International journal of molecular sciences · 2025Review
- Research priorities for physical activity and exercise management of people with knee and hip osteoarthritis: A multi-stage international priority-setting study from the OARSI Rehabilitation Discussion Group.Osteoarthritis and cartilage · 2025Article
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Using 3D MRI Bone Shape to Predict Pre-Osteoarthritis of the Knee 2 Years After Anterior Cruciate Ligament Reconstruction.The American journal of sports medicine · 2023Article
- Visualizing pre-osteoarthritis: Integrating MRI UTE-T2* with mechanics and biology to combat osteoarthritis-The 2019 Elizabeth Winston Lanier Kappa Delta Award.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Review
- Age-related changes in ACL morphology during skeletal growth and maturation are different between females and males.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Femoral Cartilage Ultrasound Echo Intensity Associates with Arthroscopic Cartilage Damage.Ultrasound in medicine & biology · 2021Article
- Deep Convolutional Neural Network-Based Diagnosis of Anterior Cruciate Ligament Tears: Performance Comparison of Homogenous Versus Heterogeneous Knee MRI Cohorts With Different Pulse Sequence Protocols and 1.5-T and 3-T Magnetic Field Strengths.Investigative radiology · 2020Article
- Concepts Important to Secondary Prevention of Posttraumatic Osteoarthritis.Journal of athletic training · 2019Article
- Anterior Cruciate Ligament Research Retreat VIII Summary Statement: An Update on Injury Risk Identification and Prevention Across the Anterior Cruciate Ligament Injury Continuum, March 14-16, 2019, Greensboro, NC.Journal of athletic training · 2019Article
- Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence.Sports (Basel, Switzerland) · 2019Review
- Italian consensus statement for the use of allografts in ACL reconstructive surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Knowledge and awareness toward anterior cruciate ligament (ACL) injury among population of Aseer region, Saudi Arabia.Journal of family medicine and primary care · 2019Article
- Abnormal Biomechanics at 6 Months Are Associated With Cartilage Degeneration at 3 Years After Anterior Cruciate Ligament Reconstruction.Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2019Article
- Scoping review of priority setting of research topics for musculoskeletal conditions.BMJ open · 2018Article
- Frontal Plane Knee Mechanics and Early Cartilage Degeneration in People With Anterior Cruciate Ligament Reconstruction: A Longitudinal Study.The American journal of sports medicine · 2018Observational
- Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes.The American journal of sports medicine · 2017Article
- Regenerative approaches for the treatment of early OA.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 8 institutions in 1 country.
Funding
Abstract
This report summarizes the 2010 AOSSM/NIH (American Orthopaedic Society for Sports Medicine/National Institutes of Health) U13 Post-Joint Injury Osteoarthritis II Conference to include the discussion concerning potential study cohorts, assessment considerations, and research priorities. There was strong consensus and enthusiasm for approaching the development of disease-modifying treatments for osteoarthritis through study of "pre-osteoarthritic" cohorts, particularly human subjects under 30 years of age following acute anterior cruciate ligament injuries. Clinical study of acute treatment strategies initiated within a few days after injury will need development of recruitment pathways and short-term proof-of-concept outcome measures that are specific to the intervention being studied. For example, measures of joint inflammation can be used in short-term prospective randomized controlled trials to determine whether an anti-inflammatory intervention was effective in decreasing early inflammation. These short-term clinical trials will need to be followed by longer-term evaluation of the clinical cohorts for joint and cartilage degeneration to determine if the acute intervention affected later development of osteoarthritis. Research priorities were identified in several disciplines, particularly regarding development and validation of quantitative imaging, biomechanics, and biomarker measures of joint structure, composition, and function that predict the accelerated development of osteoarthritis. Systematic study of posttraumatic osteoarthritis is anticipated to advance understanding and treatment of all forms of osteoarthritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.